Plasma magnesium and calcium concentrations and selected biochemical parameters in patients with type 2 diabetes mellitus
DOI:
https://doi.org/10.12923/j.2084-980X/25.2/a.02Keywords:
diabetes mellitus type 2, magnesium, calcium, lipid profileAbstract
Magnesium and calcium are known to play an important role in carbohydrate metabolism. These elements are also involved in secretion, binding, and activity of insulin. It is well-established that plasma magnesium and calcium levels in patients with diabetes mellitus are somewhat decreased. Additionally, chronic magnesium and calcium deficiency have been associated with the development of insulin resistance. Type 2 diabetes is characterized by increasing concentrations of triglycerides, total cholesterol, LDL-cholesterol and lowering of the HDL-cholesterol. Hypertriglyceridemia is often the first metabolic manifestation of insulin resistance. The purpose of this study was to determine the correlation between plasma magnesium and calcium concentrations and plasma lipids, blood glucose and glycosylated hemoglobin in type 2 diabetic patients. Magnesium and calcium concentration was determined with the colorimetric method. Lipid profile (total, HDL, LDL cholesterol, triglycerides), glycosylated hemoglobin A (HbA1c) and glucose were measured using standard methods. The plasma concentrations of glucose, HbA1c, LDL-cholesterol and triglycerides in diabetic patients were found to be significantly higher than those in the control group. The concentrations of calcium, magnesium and HDL-cholesterol were statistically lower in diabetic people in comparison to healthy individuals. In diabetic patients, a weak negative correlation was found between plasma magnesium and total cholesterol as well as between plasma magnesium and triglycerides. Positive correlations were demonstrated between plasma calcium and glycosylated hemoglobin.
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