The antibacterial activity of allyl derivatives of thiosemicarbazide, N1-thiocarbamylamidrazone, 1,2,4-triazole-5-thione, 1,3,4-(thiadiazol-2-yl) amine and derivatives of bicyclic systems: 1,2,4-triazole[3,4-b]1,3-thiazine, 1,2,4-triazole[3,2-b]1,3-thiazine, 1,3,4-thiadiazole[3,2-a]pyrimidine, thiazolo[2,3-c][1,2,4]triazole
DOI:
https://doi.org/10.12923/j.2084-980X/25.2/a.09Keywords:
allyl derivatives of thiosemicarbazide, N1-thiocarbamyl-N3-phenyl-amidrazones, 1,2,4-triazole-5-thione, 1,3,4-thiadiazol-2-yl-amine and bicyclic systems, 1,2,4-triazole[3,4-b]1,3-thiazine, thiazolo[2,3-c][1,2,4]triazole, the antimicrobial activityAbstract
The 1-acyl(aroil)-4-(allyl)cinnamyl-thiosemicarbazides (1-9), N1-allyl(cinnamyl)-thiocarbamyl-N3-phenyl-amidrazones (10-12), allyl derivatives of 1,2,4-triazole-5-thione (13-23), 1,3,4-(thiadiazol-2-yl) amine (24-29), derivatives of bicyclic systems: 1,2,4-triazole[3,4-b]1,3-thiazine (30-34), 1,2,4-triazole[3,2-b]1,3-thiazine (35), 1,3,4-thiadiazole[3,2-a]pyrimidine (36, 37), hydrazide derivatives of substituted benzoic acid (38, 39), 3,4-disubstituted-3,4,5,6-tetrahydropyrimidine-2-thione-(2-thiol) (40) and thiazolo[2,3-c][1,2,4]triazole (41-43) were screened for their in vitro activity against the reference strains of Gram-positive and Gram-negative bacteria. The compounds (11, 12, 20, 37) showed moderate activity against Gram-positive bacterial species with MIC = 31.25-62.5 µg/mL and may be of value for searching new derivatives showing better antimicrobial activity. The structure-activity relationship has been discussed.
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