Dissolution of lithium carbonate from three types extended-release capsules in paddle, basket and flow-through apparatus

Authors

  • Malgorzata Sznitowska Department of Pharmaceutical Technology, Medical University of Gdansk, Poland Author
  • Pawel Pietkiewicz Department of Pharmaceutical Technology, Medical University of Gdansk, Poland Author
  • Agnieszka Dorosz Department of Physical Chemistry with Laboratory of Instrumental Analysis, Medical University of Gdansk, Poland Author
  • Jerzy Lukasiak Department of Physical Chemistry with Laboratory of Instrumental Analysis, Medical University of Gdansk, Poland Author
  • An Vermeire Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences Ghent University, Belgium Author
  • Jean Paul Remon Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences Ghent University, Belgium Author

DOI:

https://doi.org/10.12923/j.2084-980X/25.2/a.11

Keywords:

dissolution test, pellets, minitablets, lithium carbonate, extended-release capsules

Abstract

Three types of 24-h extended-release multiparticulate capsules containing a dose of 480-504 mg lithium carbonate in a form of either pellets or 2 mm minitablets or 6 mm tablets were prepared. Dissolutions tests were performed using three different pharmacopoeial apparatus: basket, paddle and flow-through apparatus. Only capsules filled with pellets showed the same dissolution profiles, irrespective of the apparatus used in the study. In the case of two other formulations, the slowest dissolution occurred in the flow-through apparatus. The largest difference between release profiles from different apparatus was observed for the capsule filled with 6 mm tablets. The observations may indicate that probability of good reproducibility of dissolution profiles obtained in different test conditions, including change of apparatus, is related to either size or a number of the units in a capsule.

References

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Published

2012-04-01

Issue

Vol. 25 No. 2 (2012): Current Issues of Pharmacy and Medical Sciences

Section

Artykuły

License

Copyright (c) 2012 Authors

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 Unported License.

How to Cite

Sznitowska , M., Pietkiewicz , P., Dorosz, A., Lukasiak, J., Vermeire, A. ., & Remon, J. P. (2012). Dissolution of lithium carbonate from three types extended-release capsules in paddle, basket and flow-through apparatus. Current Issues in Pharmacy and Medical Sciences, 25(2), 164-167. https://doi.org/10.12923/j.2084-980X/25.2/a.11