Influence of astemizole, an H1 receptor antagonist, on the locomotors activity of carbamazepine and valproate in mice
DOI:
https://doi.org/10.12923/j.2084-980X/25.2/a.13Keywords:
exploratory locomotor activity, spontaneous locomotor activity, antiepileptic drugs, astemizole, adverse-effect profileAbstract
In the present study, we examined the influence of the second generation H1 receptor antagonist, astemizole, co-administered with carbamazepine and valproate on the exploratory and spontaneous activities in mice. Locomotor activity was monitored electronically using a Digiscan system with relation to the ambulatory and rearing activities, as well as, total distance traveled by animals within two 15-min periods. Results indicated that astemizole given alone did not affect on the three variable of motor activity, i.e. horizontal activity, total distance or vertical activity in mice. However, this H1 receptor antagonist significantly worsened horizontal and vertical activity of mice when was co-administered with valproate or carbamazepine in exploratory time. Moreover, it decreased total distance in combination with carbamazepine evaluated in spontaneous time. Our data clearly indicated that even newer generation of histamine receptor antagonists should be used with caution in patients suffering on epilepsy. It should be stressed that combined treatment of astemizole with carbamazepine or valproate may be clinically hazardous.
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