Assessment of oxidative stress parameters in rats pretreated with Ukrain and amitriptyline
DOI:
https://doi.org/10.12923/j.2084-980X/25.3/a.09Keywords:
Ukrain, amitriptyline, oxidative stress, ratsAbstract
Our research aimed to evaluate the oxidant-antioxidant balance in rats exposed to the Ukrain and AMI drugs. The effect of 14-day administration of these drugs on selected parameters of oxidative stress in blood of rats has been investigated. The activity of antioxidant enzymes, namely glutathione peroxidase (GPX) and reductase (GR), and Total Antioxidant Status (TAS) were determined. It was noted that combined 14-day use of Ukrain (14 or 28 mg/kg) and AMI (10 mg/kg) significantly increased TAS and did not affect the activity of GPX and GR in comparison to groups receiving only Ukrain or AMI alone. While Ukrain administered to rats for 14 days in the above doses did not affect either the activity of the enzymes assayed or the level of TAS. After 2-week treatment with AMI at a dose of 10 mg/kg any statistically significant change of the enzymes activitiy or TAS concentration was not reported either, compared with the control group. The results indicate the beneficial effect of the combination of Ukrain and AMI drugs on the oxidant-antioxidant balance and increasing the antioxidant status in rats.
References
1. Bilska A., Kryczyk., Włodek L.: Różne oblicza biologicznej roli glutationu (The different aspects of the biological role of glutathione). Postępy Hig. Med. Dośw., 61, 438, 2007.
2. Drelich G. Lewandowska-Stanek H., Jagiełło-Wójtowicz E.: Zachwianie równowagi oksydoredukcyjnej w samobójczych zatruciach lekami przeciwdepresyjnymi (Imbalance of oxidoreductive status in suicidal antidepressant drugs poisoning). Przegl. Lek., 64 (4-5), 258, 2007.
3. Gansauge F. et al.: The clinical efficacy of adjuvant systemic chemotherapy with gemcitabine and NSC-631570 in advanced pancreatic cancer. Hepatogastroenterology, 54 (75), 917, 2007.
4. Gawrońska-Grzywacz M. et al.: Influence of combined administration of Ukrain and tricyclic antidepressants on basic biochemical serum parameters of kidney function in rats. Ann. UMCS Sect. DDD, 24 (2), 17, 2011.
5. Gawrońska-Grzywacz M., Herbet M., Jagiełło-Wójtowicz E.: Effect of simultaneous treatment with Ukrain and amitriptyline on selected biochemical serum parameters in rodents. Ann. UMCS Sect. DDD, 23 (4), 129, 2010.
6. Gołacka E.: Zatrucia lekami z grupy TCA w materiale Regionalnego Ośrodka Toksykologii Klinicznej w Lublinie w roku 2002. Przegl. Lek., 60, 289, 2003.
7. Haduch A., Wójcikowski J., Daniel W. A.: The effect of tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs) and newer antidepressant drugs on the activity and level of rat CYP3A. Eur. Neuropsychopharmacol., 16, 178, 2006.
8. Hawton K. et al.: Toxicity of antidepressants: rates of suicide relative to prescribing and non-fatal overdose. Br. J. Psychiatry, 196 (5), 354, 2010.
9. Jagiełło-Wójtowicz E. et al.: Ukrain (NSC-631570) in experimental and clinical studies: a review. Drugs Exptl. Clin. Res., 24 (5), 213, 1998.
10. Jagiełło-Wójtowicz E., Izdebska M.: Evaluation of antioxidative activity of Ukrain in alcohol-intoxicated rats. Ann. UMCS Sect. DDD, 20 (2), 175, 2007.
11. Kautio A. L. et al.: Amitriptyline in the prevention of chemotherapy-induced neuropathic symptoms. Anticancer Res., 29 (7), 2601, 2009.
12. Kautio A. L. et al.: Amitriptyline in the treatment of chemotherapy-induced neuropathic symptoms. J. Pain Symptom Manage., 35 (1), 31, 2008.
13. Kubera M., Basta-Kaim A., Górka Z.: The effect of amitriptyline on the cell-mediated immunity of stressed rats. Pol. J. Pharmacol., 47, 137, 1995.
14. Nowicky J. W. et al.: Ukrain both as anticancer and immunoregulatory agent. Drugs Exptl. Clin. Res., 18, 51, 1992.
15. Pasquini M. et al.: Detection and treatment of depressive and anxiety disorders among cancer patients: feasibility and preliminary findings from a liaison service in an oncology division. Depress. Anxiety, 23 (7), 441, 2006.
16. Uglyanitsa K. N. et al. : Ukrain: A novel antitumor drug. Drugs Exptl. Clin. Res., 26 (5), 341, 2000.
17. Zabłocka A., Janusz M.: Dwa oblicza wolnych rodników tlenowych (The two faces of reactive oxygen species). Postępy Hig. Med. Dośw., 62, 118, 2008.
Downloads
Published
Issue
Section
License
Copyright (c) 2012 Author
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 Unported License.
