Influence of fluphenazine dihydrochloride on model dipalmitoylphosphatidylcholine membranes and human genotoxically damaged lymphocyte cultures
DOI:
https://doi.org/10.12923/j.2084-980X/25.3/a.11Keywords:
chemosensitizing agents, differential scanning calorimetry, fluphenazine dihydrochloride, membrane interactions, P-glycoprotein, rhodamine 123Abstract
The membrane interactions can play a vital role in chemosensitizing activity of fluphenazine dihydrochloride, an inhibitor of P-glycoprotein transport function. In in vitro testings of the influence of fluphenazine dihydrochloride on model dipalmitoylphosphatidylcholine membranes and on human lymphocyte cultures, genotoxically damaged by benzo[a]pyrene, differential scanning calorimetry and rhodamine 123 retention test were applied. The results of both testings shown that the membrane interactions of fluphenazine dihydrochloride in model membrane structure and the chemosensitizing effect of this compound in examined human lymphocyte cultures, depend on its concentration in a sample.
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