Application of sHS/GC-MS method for the identification of paracetamol impurities in the selected pharmaceutical formulations

Authors

  • Rafał Pietraś Department of Medicinal Chemistry, Medical University of Lublin, Poland Author
  • Agnieszka Staszewska Department of Medicinal Chemistry, Medical University of Lublin, Poland Author
  • Anna Gumieniczek Department of Medicinal Chemistry, Medical University of Lublin, Poland Author
  • Dorota Kowalczuk Department of Medicinal Chemistry, Medical University of Lublin, Poland Author

DOI:

https://doi.org/10.12923/j.2084-980X/25.3/a.18

Keywords:

paracetamol, impurities, headspace analysis, GC-MS

Abstract

Simple and rapid quantitative procedure based on gas chromatography mass spectrometry in combination with static headspace was developed for the identification of paracetamol and its impurities in commercially available analgesic tablets. The proposed procedure provides relevant analytical results and an uncomplicated sample procedure. Samples were separated on HP5-ms capillary column using helium (1.5 ml min-1) as carrier gas. The qualitative identification of analysed compounds was carried out on a triple quadrupole mass spectrometer in scan mode equipped with electron impact ionisation (EI) and recognised by NIST Library (NIST Library match > 90%). The elaborated procedure is suitable for the identification of paracetamol, its impurities (N-phenylacetamide. N-(2-hydroxyphenyl)acetamide) and volatile organic compounds.

References

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Published

2012-07-01

Issue

Vol. 25 No. 3 (2012): Current Issues of Pharmacy and Medical Sciences

Section

Artykuły

License

Copyright (c) 2012 Authors

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 Unported License.

How to Cite

Pietraś, R., Staszewska, A., Gumieniczek, A., & Kowalczuk, D. (2012). Application of sHS/GC-MS method for the identification of paracetamol impurities in the selected pharmaceutical formulations. Current Issues in Pharmacy and Medical Sciences, 25(3), 303-305. https://doi.org/10.12923/j.2084-980X/25.3/a.18