Dependence of analytical parameters of ion-selective electrodes on the membrane solvents used in the construction of membranes
DOI:
https://doi.org/10.12923/j.2084-980X/25.3/a.24Keywords:
ion-selective electrode, potentiometric titration, drug analysis, solvent mediators, fluoxetine hydrochloride determination, diazepam determinationAbstract
The aim of this study was analysis of the suitability of available membrane solvents and their application to obtain liquid membrane ion-selective electrodes that are sensitive to diazepam or fluoxetine. Sensitive and reasonably selective poly(vinyl chloride) membrane electrodes are based on using water insoluble ion-pair of diazepam – [tetrakis(3,5bis-(trifluoromethyl)phenyl]borate or fluoxetine – [tetrakis(4-fluorophenyl)]borate as electroactive material. As membrane solvents for construction of membranes there were used 2-nitrophenyloctyl ether, bis(2-ethylhexyl) sebacate, 1-isopropyl-4-nitrobenzene, bis (1-buthylpentyl) adipate, tris(2-ethylhexyl) phosphate. Evaluation of analytical parameters of the obtained electrodes, their selectivity and evaluation of analytical parameters for membranes subjected to a process of "accelerated aging" in a climate chamber at 60 °C and humidity of 70 % without the VIS and UV light, were developed. There was carried out an analysis of the suitability of the electrodes, which will show the best stability and reproducibility of the analytical parameters for the determination of substances in respect of which exhibit selectivity. The determination was developed using potentiometric titration method.
References
1. Al Attas A.S.: Construction and analytical application of ion selective bromazepam sensor. Int. J. Electrochem. Sci. 4, 20, 2009.
2. Alaa Eldin A.S. et al.: Potentiometric determination of some 1,4-benzodiazepines in pharmaceutical preparations and biological samples. J. Electroanal. Chem. 536, 1, 2002.
3. Ammar R.A., Otaif H., Al-Warthan A.: Quantitative determination of duloxetine hydrochloride in pharmaceuticals and urine using prepared ion selective membrane electrode. International J. Electrochem. Sci. 7, 2531, 2012.
4. Craggs A., Moody G.J., Thomas J.D.R.: PVC matrix membrane ion-selective electrodes. J. Chem. Ed. 51, 541, 1974.
5. Dobaria N.B., Shah S.G., Rajput S.J.: Development of novel plastic membrane ion-selective electrode for metformin hydrochloride. Indian J. Pharm. Sci. 68, 562, 2006.
6. Drozd J., Hopkała H.: Cyproheptadine ion-selective electrodes and their applications in some pharmaceutical formulations. Desalination 163, 119, 2004.
7. El-Naby E.H.: Polymeric membrane sensors for the selective determination of dextromethorphan in pharmaceutical preparations. Anal. Sci. 24, 1409, 2008.
8. Eugster R. et al.: Plasticisers for liquid polymeric membranes of ion-selective chemical sensors. Anal. Chim. Acta 289, 1, 1994.
9. Gupta V.K., Agarwal S., Singhal B.: Potentiometric assay of antipsychotic drug (Ziprasidone Hydrochloride) in pharmaceuticals, serum and urine. Int. J. Electrochem. Sci. 6, 3036, 2011.
10. Gupta V.K., Singh A.K., Gupta B.: Potentiometric sensor for the high throughput determination of tetramisole hydrochloride. Comb. Chem. High T. Scr. 10, 583, 2007.
11. Hassouna M.E.M., Elsuccary S.A.A.: PVC membrane electrode for the potentiometric determination of Ipratropium bromide using batch and flow injection techniques. Talanta 75, 1175, 2008.
12. Ibrahim H., Issa Y.M., Abu-Shawish H.M.: Potentiometric flow injection analysis of dicyclomine hydrochloride in serum, urine and milk. Anal. Chim. Acta 532, 79, 2005.
13. Jalali F., Arkan E., Bahrami G.: Preparation of a gabapentin potentiometric sensor and its application to pharmaceutical analysis. Sensor. and Actuat. B-Chem. 127, 304, 2007.
14. Khalil S., Kelzieh A.: New polyvinyl chloride membrane electrode without inner reference solution for the determination of methadone. J. Pharmaceut. Biomed. Anal. 31, 601, 2003.
15. Malongo T.K. et al.: Amodiaquine polymeric membrane electrode. J. Pharmaceut. Biomed. Anal. 41, 70, 2006.
16. Nassory N.S., Maki S.A., Al-Phalahy B.A.: Preparation and potentiometric study of promethazine hydrochloride selective electrodes and their use in determining some drugs. Turk. J. Chem. 32, 539, 2008.
17. Pungor E., Toth K., Hrabeczy-Pall A.: Selectivity coefficients of ion-selective electrodes. Pure & Appl. Chem. 1913, 51, 1979.
18. Sales M.G.F., Tomás J.F.C., Lavandeira S.R.: Flow injection potentiometric determination of chlorpromazine. J. Pharmaceut. Biomed. Anal. 41, 1280, 2006.
19. Shawish H.M.A. et al.: Effect of plasticizers and ion-exchangers on the detection limit of tramadol-PVC membrane electrodes. Eurasian J. Anal. Chem. 6, 70, 2011.
20. Siska E., Pungor E.: Potentiometric determination of tetraphenylborate ions with silver nitrate. Determination of silver, potassium and tallium. (I) Z. Anal. Chem. 257, 12, 1971.
21. Wassil A.A., El-Ftaah Bastawy Farag A., Moukdad F.A.: Polymer membrane electrodes for sensitive potentiometric determination of β-blockers. Drug Dev. Ind. Pharm. 33, 57, 2007.
22. Wołyniec E. et al.: Batch and flow-injection determination of catecholamines using ion selective electrodes. Instr. Sci. Technol. 35, 241, 2007.
23. Zayed S.I.M., Issa Y.M.: Sibutramine selective electrodes for batch and flow injection determinations in pharmaceutical preparations. Anal. Sci. 26, 45, 2010.
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