Gamma-glutamyl transferase (GGT) activity and lipid concentration in patient with coronary artery disease (CAD)
DOI:
https://doi.org/10.12923/j.2084-980X/25.4/a.03Keywords:
gamma-glutamyl transferase, GGT, high-sensitivity C reactive protein, (hsCRP), stable coronary artery disease , CADAbstract
A serum lipid profiles are established risk factors for atherosclerosis. High sensitivity C-reactive protein (hsCRP) level, are a powerful predictor of future myocardial infarction and cardiac death among apparently healthy individuals. The aim of this study was to investigate serum GGT activity and hsCRP level and others atherosclerosis biochemistry markers in patients with stable coronary artery disease. We studied 94 (women, n=45 and men, n=49), mean age was 64.8±9.7 years, consecutive patients with stable coronary artery disease (CAD), hospitalized in the Department of Cardiology Cardinal Wyszyński Hospital in Lublin. Patients with acute coronary syndroms (ACS) in history where 53% (n=51) of studied population (unstable angina n=3; no ST elevation myocardial infarction n=17, ST elevation myocardial infarction n=31). The patients with acute and chronic kidney disease, liver diseases, active autoimmune disease, malignancy, thyroids diseases, alcohol disease were excluded from the analysis. The patients had worse laboratory parameters than the reference group. They had increased concentration of TG, hsCRP and GGT activity, and decreased concentration of HDL-C as compared to the reference group. However, ALT activity and creatinine concentration were non-significantly increased vs. the controls. We concluded that dyslipidemia together with GGT activity and hsCRP concentration may be good markers to predict cardio-vascular events and vessels lesions in asymptomatic patients with CAD. However, these results require further studies.
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