Keywords
phenobarbital
releasing
Abstract
Five nonisotonised emulsions with different degree of compaction containing 1% solution of phenobarbital in soybean oil, lecithin, human albumin and four concentrated emulsions with the same composition containing the addition of isotonic agents such as: glucose, sodium chloride, Ringer salt, glycerin were prepared. The release of phenobarbital was examined by dialysis through the semipermeable membrane using the modified Franz diffusion cell. The studies show that the release is a diffuse. Phenobarbital releases with a lag time and the process is biphasic; first faster, in the second stage slower. The release of phenobarbital depends on the amount of external phase (water) in nonisotonised emulsions and on the kind of using isotonic agent in concentrated emulsions.
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