The changes of NO-synthases activity, nitrogen oxide content and lipoperoxidation processes in stomach and colon under conditions of streptozocin-induced hyperglycaemia
DOI:
https://doi.org/10.12923/j.2084-980X/25.4/a.22Keywords:
NO-synthase, nitrogen oxide, lipoperoxidation, stomach, hyperglycaemiaAbstract
In rats with streptozocin-induced hyperglycaemia the changes of nos activity, nitrite anion content and lipoperoxidation processes in mucous and muscular layers of the stomach and large intestine were studied. It has been showed that hyperglycaemia induces the decrease of cnos activity in mucous layer, while its activity in muscular layer of the stomach and large intestine did not change significantly and іnos activity increased in muscular layer of the stomach and large intestine. Nitrite anion content did not change significantly. Hyperglycaemia caused an increase of the lipoperoxidation processes in mucous and muscular layers of the large intestine; simultaneously sod activity in mucous and muscular layer increased.
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