Analysis of expression profile of genes encoding cell adhesion proteins in endometrial cancer
DOI:
https://doi.org/10.12923/j.2084-980X/25.4/a.25Keywords:
endometrial cancer, expression profile of genes, adhesion proteinsAbstract
Endometrial cancer is one of the most common gynecological malignancies. Unfortunately, molecular pathogenesis of this neoplasm remains poorly understood. Using MacroArray technique, we analyzed expression profile of genes encoding adhesion proteins in neoplastic tissue derived from 40 patients diagnosed with the endometrial cancer between 2003 and 2004. Analysis of statistic dependences between gene expression profiles and tumor grade pointed out thirteen genes encoding adhesion proteins (cadherin-1, -5, -8, -13, -15, integrin alpha-1, -6, integrin beta-1, -8, zyxin related protein-1, paxillin, catenin alpha-1), which are significantly over- or under-expressed (11 and 2 genes respectively) depending of tumor grade. Taking under consideration clinical stage of the cancer we pointed out eleven genes (integrin alpha-8, integrin beta-1, -3, cadherin-8, -15, catenin beta-1, paxillin, trombospondin-2, ninjurin-1, desmocollin-3) encoding proteins crucial for cell-cell interaction those expressions were altered showing statistically significance for different clinical stage according to FIGO classification.
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