Keywords
postprandial hyperglycemia
NO
histochemistry
fucosylated glycans
Abstract
The present study was designed to evaluate the role of postprandial hyperglycemia (PHG) on oesophageal epithelial barrier (OEB) integrity via evaluation expression of fucosylated glycans by PFA and LABA labeling and mechanism in formation PHG induced pre-ulcer lesions through the NO/NOS activity in OEB and therapeutic potential and mechamism of L-Tryptophan influence on OEB lesions. Fucosaylated glycans are contributed in OEB integrity. NO/NOS activity seem to play a critical role in OEB ulcerogenesis because blocking its activity aggravates experimental OEB lesions, most likely through the inflammation, vascular and perivascular changes.
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