Diagnosis of experimental stetohepatosis using ultrasound shear wave elastography

Authors

  • Petro Bodnar National Bohomolets University, Kiev, Ukraine Author
  • Oleg Dynnyk Medical Theoretical and Practical Association «Medstroj», Ukraine Author
  • Galyna Myhalchyshyn National Bohomolets University, Kiev, Ukraine Author
  • Tetiana Beregova UNN «Biology lnstitute» of Kiev National Shevchenko University, Ukraine Author
  • Nazariy Kobyliak National Bohomolets University, Kiev, Ukraine Author
  • Iryna Prybytko UNN «Biology lnstitute» of Kiev National Shevchenko University, Ukraine Author
  • Mariana Kondro Lviv National Medical University of Danylo Galytsky, Ukraine Author

DOI:

https://doi.org/10.12923/j.2084-980X/26.1/a.24

Keywords:

steatohepatosis, non-alcoholic fatty liver disease, ultrasound liver elastography

Abstract

According to available literature data, NAFLD may play crucial role in the pathogenesis of type 2 diabetes and other conditions connected with insulin resistance. In order to study the essence of the NAFLD, we have created an experimental model of the steatohepatosis. The mixed diet for 8 weeks consisting of standard food (47%), sweetened condensed milk (44%), vegetable oil (8%) and vegetable starch (1%) develops non-alcoholic steatohepatosis in the animals undergoing the experiment. The morphological signs of the non-alcoholic steatohepatosis comprised as follows in the hepatocytes of the rats undergoing the experiment: presence of fine-drop fattiness (fine-drop steatosis) and accumulation of fat vacuoles shifting the nucleus towards the cell peripheral. Substantial increase in the liver pulp of the animals undergoing the experiment defined using the ultrasound shear wave elastography technique is indicative of the presence of the non-alcoholic steatohepatosis. The ultrasound shear wave elastography technique can be used as a non-invasive diagnosis marker of the non-alcoholic steatohepatosis. The said diagnosis technique has been recommended for the first time.

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Published

2013-03-29

Issue

Vol. 26 No. 1 (2013): Current Issues of Pharmacy and Medical Sciences

Section

Artykuły

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Copyright (c) 2013 Authors

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 Unported License.

How to Cite

Bodnar, P., Dynnyk, O., Myhalchyshyn, G., Beregova, T., Kobyliak, N., Prybytko, I., & Kondro, M. (2013). Diagnosis of experimental stetohepatosis using ultrasound shear wave elastography. Current Issues in Pharmacy and Medical Sciences, 26(1), 109-113. https://doi.org/10.12923/j.2084-980X/26.1/a.24