The influence of coating on release of paracetamol from the multi-compartment systems
DOI:
https://doi.org/10.12923/j.2084-980X/26.2/a.09Keywords:
multi-compartment system, modified release, minitablets, coated tablets, paracetamolAbstract
A multi-compartment system enables modification of medicinal substance release. Nine series of multi-compartment systems were prepared, where each contained 5 minitablets. Application of different envelopes (OPADRY II WHITE and ACRYL EZE – PINK), coating the individual minitablets and complete multi-compartment systems, allowed for modeling medicinal substance release from the tested drug forms. Dissolution test of paracetamol was tested. The results were processed using the Statistica 9.0 (StatSoft, USA).
References
1. Bauer K., Frömming K-H., Führer C.: Technologia postaci leku z elementami biofarmacji. Wyd. 8. Wrocław: MedPharm Polska, 2012.
2. Funaro C. Et al.: Minitablets coated in a solid-wall pan for theophylline sustained-release capsules. Pharm. Tech. Drug Delivery, 38, 38-42, 2010.
3. Greb E.: The Hour of the Particle. Pharm. Tech. 38, 38-42, 2010.
4. Haznar D., Garbacz G.: Wybrane aspekty technologii leków o modyfikowanym uwalnianiu. Farm. Pol., 65(10), 749-755, 2009.
5. Janicki S.: Urzeczywistnienie Idei Leku Wielokompartmentowego. Farm. Pol., 55(3), 139-148, 1999.
6. Janicki S., Pietkiewicz P., Skrabalak M.: Otrzymywanie i dostępność farmaceutyczna paracetamolu w postaci modelu wielokompartmentowego. Farm. Pol., 57(4) 163-166, 2001.
7. Sawicki W., Łepek P., Kleina M.: Otoczki na tabletkach i peletkach – budowa, funkcja, mechanizm i metody powlekania. Farm. Pol., 66 (5), 378-382, 2010.
8. Słodownik T.: Postęp w technologii kapsułek. Gazeta Farmaceutyczna, 2 (38), 38-40, 2008.
9. Wikstrand J.: Achieving optimal beta1-blockade with metoprolol CR/Zok. Basic Res. Cardiol., 95, 46-51, 2000.
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