The impact of Body Mass Index (BMI) on mortality rates in patients with severe burns

Authors

  • Zofia M. Górecka 1 East Centre of Burns Treatment and Reconstructive Surgery, Independent Public District Hospital in Leczna, Poland; 2 Independent Public Clinical Hospital No. 4 in Lublin, Department of Plastic and Reconstructive Surgery and Microsurgery, Medical University of Lublin, Poland Author https://orcid.org/0009-0001-3930-6213
  • Agnieszka Surowiecka 1 East Centre of Burns Treatment and Reconstructive Surgery, Independent Public District Hospital in Leczna, Poland; 2 Independent Public Clinical Hospital No. 4 in Lublin, Department of Plastic and Reconstructive Surgery and Microsurgery, Medical University of Lublin, Poland Author https://orcid.org/0000-0003-3360-716X
  • Patrycja Klein Non-Public Healthcare Institution, Farmed, Lublin, Poland Author https://orcid.org/0009-0004-7558-890X
  • Aleksander Sławiński Infectious Diseases Clinic, Institute of Rural Health, Lublin, Poland Author https://orcid.org/0000-0002-3457-7268
  • Grzegorz Wilhelm Independent Public Clinical Hospital No. 4 in Lublin, Department of Plastic and Reconstructive Surgery and Microsurgery, Medical University of Lublin, Poland Author https://orcid.org/0000-0002-2052-8334
  • Marek Majewski Independent Public Clinical Hospital No. 4 in Lublin, Department of Plastic and Reconstructive Surgery and Microsurgery, Medical University of Lublin, Poland Author https://orcid.org/0000-0001-5363-9818
  • Tomasz Korzeniowski East Centre of Burns Treatment and Reconstructive Surgery, Independent Public District Hospital in Leczna, Poland Author https://orcid.org/0000-0002-7610-1460
  • Kamil Torres 1 Independent Public Clinical Hospital No. 4 in Lublin, Department of Plastic and Reconstructive Surgery and Microsurgery, Medical University of Lublin, Poland; 2 Infectious Diseases Clinic, Institute of Rural Health, Lublin, Poland Author https://orcid.org/0000-0001-5602-3744
  • Jerzy Strużyna 1 East Centre of Burns Treatment and Reconstructive Surgery, Independent Public District Hospital in Leczna, Poland; 2 Independent Public Clinical Hospital No. 4 in Lublin, Department of Plastic and Reconstructive Surgery and Microsurgery, Medical University of Lublin, Poland Author https://orcid.org/0000-0002-3064-3379

DOI:

https://doi.org/10.12923/cipms-2025-0017

Keywords:

obesity, body mass index, burns, mortality

Abstract

There is an increase in the number of obese patients in burn units. Obesity is strongly associated with metabolic syndrome and chronic diseases, including cardiovascular and gastrointestinal disorders and diabetes. However, there is evidence that moderate obesity and overweight have a potentially protective effect on mortality among severely burned patients. The “obesity paradox” may result from the protective effect of adipose tissue due to its thermal conductivity and the regenerative potential resulting from the presence of mesenchymal stem cells in the subcutaneous tissue. This review aims to summarize available data showing correlation between Body Mass Index (BMI; kg/m2) and clinical outcome of the treatment of burns, including its impact on mortality. We pointed out direction of further research that should be conducted to more precisely examine the relationship between weight and course of treatment of burn patients. A systemic search was conducted of the relevant literature up to and including July 2024 – using database PubMed.

The presented articles confirm the J-shaped and U-shaped correlation between BMI and mortality in burn patients. Being overweight or moderately obese proved to be protective compared to having a normal BMI or more severe obesity. Obesity is undoubtedly associated with several adverse health effects and requires additional challenges for health care in the process of treating its undesirable effects. However, the presented articles prove that overweight and obesity can have a protective effect on patients with severe burns.

References

1. Strużyna J, editor. Wczesne leczenie oparzeń. Warszawa: Wydawnictwo Lekarskie PZWL; 2006:326.

2. Clark A, Imran J, Madni T, Wolf SE. Nutrition and metabolism in burn patients. Burns Trauma. 2017;5.

3. Indicator Metadata Registry Details. [https://www.who.int/data/gho/indicator-metadata-registry/imr-details/3420#] (access: 9.08.2024).

4. Lester ELW, Dvorak JE, Maluso PJ, Bendjemil S, Messer T, Poulakidas S, et al. Obesity paradox in the burn patient. J Burn Care Res. 2020;41(1):30-2.

5. Wu Y, Li D, Vermund SH. Advantages and limitations of the Body Mass Index (BMI) to assess adult obesity. Int J Environ Res Public Health. 2024;21(6):757.

6. Wolfe RR, Herndon DN, Peters EJ, Jahoor F, Desai MH, Holland OB. Regulation of lipolysis in severely burned children. Ann Surg. 1987;206(2):214-21.

7. Knuth CM, Auger C, Jeschke MG. Burn-induced hypermetabolism and skeletal muscle dysfunction. Am J Physiol-Cell Physiol. 2021;321(1):C58-71.

8. Schetz M, De Jong A, Deane AM, Druml W, Hemelaar P, Pelosi P, et al. Obesity in the critically ill: a narrative review. Intensive Care Med. 2019;45(6):757-69.

9. Al-Tarrah K, Jones SW, Moiemen N, Lord JM. Potential role of adipose tissue and its hormones in burns and critically III patients. Burns. 2020;46(2):259-66.

10. Sasaki M, Abe R, Fujita Y, Ando S, Inokuma D, Shimizu H. Mesenchymal stem cells are recruited into wounded skin and contribute to wound repair by transdifferentiation into multiple skin cell type. J Immunol. 2008;180(4):2581-7.

11. Gauglitz GG, Song J, Herndon DN, Finnerty CC, Boehning D, Barral JM, et al. Characterization of the inflammatory response during acute and post-acute phases after severe burn. Shock. 2008;30(5):503-7.

12. Surowiecka A, Chrapusta A, Klimeczek-Chrapusta M, Korzeniowski T, Drukała J, Strużyna J. Mesenchymal stem cells in burn wound management. Int J Mol Sci. 2022;23(23):15339.

13. Jian-Xing D, Wen-Jun L, Yue-Qin Z, Wang D, Gao-Fei Z, Jia-Mei L, et al. Umbilical cord mesenchymal stem cells for inflammatory regulation after excision and grafting of severe burn wounds in rats. J Burn Care Res. 2021;42(4):766-73.

14. Çakır B, Çevik H, Contuk G, Ercan F, Ekşioğlu-Demiralp E, Yeğen BÇ. Leptin ameliorates burn-induced multiple organ damage and modulates postburn immune response in rats. Regul Pept. 2005;125(1-3):135-44.

15. Pradhan G, Samson SL, Sun Y. Ghrelin: much more than a hunger hormone. Curr Opin Clin Nutr Metab Care. 2013;16(6):619-24.

16. Heymsfield SB, Cefalu WT. Does Body Mass Index adequately convey a patient’s mortality risk? JAMA. 2013;309(1):87.

17. Liu NT, Fenrich CA, Serio-Melvin ML, Peterson WC, Cancio LC, Salinas J. The impact of patient weight on burn resuscitation. J Trauma Acute Care Surg. 2017;83(1):S112-9.

18. Liodaki E, Senyaman Ö, Stollwerck PL, Möllmeier D, Mauss KL, Mailänder P, et al. Obese patients in a burn care unit: A major challenge. Burns. 2014;40(8):1738-42.

19. Tobiasen J, Hiebert JM, Edlich RF. The abbreviated burn severity index. Ann Emerg Med. 1982;11(5):260-2.

20. Eichenberger AS, Proietti S, Wicky S, Frascarolo P, Suter M, Spahn DR, et al. Morbid obesity and postoperative pulmonary atelectasis: An underestimated problem. Anesth Analg. 2002;95(6):1788-92.

21. Ghanem AM, Sen S, Philp B, Dziewulski P, Shelley OP. Body Mass Index (BMI) and mortality in patients with severe burns: Is there a “tilt point” at which obesity influences outcome? Burns. 2011;37(2):208-14.

22. Carpenter AM, Hollett LP, Jeng JC, Wu J, Turner DG, Jordan MH. How long a shadow does epidemic obesity cast in the burn unit? A dietitian’s analysis of the strengths and weaknesses of the available data in the national burn repository. J Burn Care Res. 2008;29(1):97-101.

23. Fleischmann E, Teal N, Dudley J, May W, Bower JD, Salahudeen AK. Influence of excess weight on mortality and hospital stay in 1346 hemodialysis patients. Kidney Int. 1999;55(4):1560-7.

24. Logue J, Walker JJ, Leese G, Lindsay R, McKnight J, Morris A, et al. Association between BMI measured within a year after diagnosis of Type 2 diabetes and mortality. Diabetes Care. 2013;36(4):887-93.

25. Bijani A, Cumming RG, Hosseini SR, Yazdanpour M, Rahimi M, Sahebian A, et al. Obesity paradox on the survival of elderly patients with diabetes: an AHAP-based study. J Diabetes Metab Disord. 2018;17(1):45-51.

26. Lin JC, Zheng JJ, Wu GH, Chen ZH, Chen XD, Jiang Q. Differences by age in the obesity paradox in severe burns. Burns. 2022;48(3):547-54.

27. Jeschke MG, Finnerty CC, Emdad F, Rivero HG, Kraft R, Williams FN, et al. Mild obesity is protective after severe burn injury. Ann Surg. 2013;258(6):1119-29.

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Published

2025-05-21

How to Cite

Górecka, Z. M., Surowiecka, A., Klein, P., Sławiński, A., Wilhelm, G., Majewski, M., Korzeniowski, T., Torres, K., & Strużyna, J. (2025). The impact of Body Mass Index (BMI) on mortality rates in patients with severe burns. Current Issues in Pharmacy and Medical Sciences, 38(2 (AOP). https://doi.org/10.12923/cipms-2025-0017