Impact of vitamin D deficiency on reproductive dysfunction in West Algeria women of reproductive age
DOI:
https://doi.org/10.12923/cipms-2025-0008Keywords:
female fertility, hormones, Hypovitaminosis D, infertility duration, vitamin D supplementationAbstract
In addition to sex steroid hormones, vitamin D has a modulatory reproductive action due to the vitamin D receptor and vitamin D metabolizing enzymes that are found in human reproductive tissues. This study aimed to evaluate and explore the impact of vitamin D on female infertility. Authors conducted a prospective study of 394 infertile women from the region of Tiaret (western Algeria).
Authors study revealed a predominance of hypovitaminosis in 80.8% of all patients, with no significant relationship between vitamin D status and age. However, a significant association between residence, Body Mass Index and vitamin D was found (P<0.0001). The association of 25(OH)D and certain pathologies (Polycystic ovary syndrome, endometriosis, miscarriage and irregular menstrual cycle) was very significant (P<0.0001). Women with vitamin D deficiency were the most affected by uterine and ovarian abnormalities. An inverse correlation was highlighted between vitamin D and different hormones, infertility duration and supplementation. Moreover, women with long lasting infertility (55-96 months and over 96 months) were deficient in vitamin D (31.3% and 19.5%, respectively). In addition, miscarriages were more noted in vitamin D deficient women (96 cases, 36.6%); however, the majority of women with normal vitamin D status had no history of miscarriages (93.3%) P χ2<0.0001.
Hypovitaminosis D is associated with long durations of infertility, high number of miscarriages, a significant prevalence of Polycystic ovary syndrome, irregular menstrual cycles. Thus, good control of vitamin D status is a necessity for improving female fertility.
References
1. Bhattarai HK, Shrestha S, Rokka K, Shakya R. Vitamin D, Calcium, parathyroid hormone, and sex steroids in bone health and effects of aging. J Osteoporos. 2020;2020:1-10.
2. Da Silveira EA, Moura LDANE, Castro MCR, Kac G, Hadler MCCM, Noll PRES, et al. Prevalence of vitamin D and calcium deficiency and insufficiency in women of childbearing age and associated risk factors: A systematic review and meta-analysis. Nutrients. 2022;
14(20):4351.
3. Al Faris NA, Al Kehayez NM, Al Mushawah FI, Al Naeem AN, Al Amri ND, Al Mudawah ES. Vitamin D deficiency and associated risk factors in women from Riyadh, Saudi Arabia. Sci Rep. 2019;9(1):
20371.
4. Jueraitetibaike K, Ding Z, Wang DD, Peng LP, Jing J, Chen L, et al. The effect of vitamin D on sperm motility and the underlying mechanism. Asian J Androl. 2019;21(4):400.
5. Hrabia A, Kamińska K, Socha M, Grzesiak M. Vitamin D3 receptors and metabolic enzymes in hen reproductive tissues. IJMS. 2023;24(23):17074.
6. [https://www.who.int/news-room/fact-sheets/detail/infertility]
7. Collée J, Mawet M, Tebache L, Nisolle M, Brichant G. Polycystic ovarian syndrome and infertility: overview and insights of the putative treatments. Gynecol Endocrinol. 2021;37(10):869-74.
8. Zauner G, Girardi G. Potential causes of male and female infertility in Qatar. J Reprod Immunol. 2020;141:103173.
9. Gruber TM, Mechsner S. Pathogenesis of endometriosis: The origin of pain and subfertility. Cells. 2021;10(6):1381.
10. Nasreen K, Ishrat S, Banu J, Fatima P, Ansary SA, Jahan I, et al. Comparison of vitamin D (25OHD) status between fertile and infertile men. Int J Reprod Contracept Obstet Gynecol. 2021;
10(4):1303.
11. Grzesiak M. Vitamin D3 Action within the ovary – an updated review. Physiol Res. 2020; 69(3): 371-8.
12. Hadri Z, Benada M, Djellouli M, Boudalia S, Rahali A, Araf A. Prevalence of obesity and effect of sport activity on university students in Algeria. Sci Afr. 2022;17:e01319.
13. Karampela I, Sakelliou A, Vallianou N, Christodoulatos GS, Magkos F, Dalamaga M. Vitamin D and obesity: Current evidence and controversies. Curr Obes Rep. 2021;10(2):162-80.
14. Vranić L, Mikolašević I, Milić S. Vitamin D deficiency: consequence or cause of obesity? Medicina. 2019;55(9):541.
15. Holick MF, Slominski AT. Photobiology of vitamin D. In: Feldman and Pike’ s Vitamin D. Elsevier; 2024:27-45.
16. Fung JL, Hartman TJ, Schleicher RL, Goldman MB. Association of vitamin D intake and serum levels with fertility: results from the lifestyle and fertility study. Fertil Steril. 2017;108(2):302-11.
17. Azhar A, Abid F, Rehman R. Polycystic ovary syndrome, subfertility and vitamin d deficiency. J Coll Physicians Surg Pak. 2020;
30(05):545-6.
18. Di Bari F, Catalano A, Bellone F, Martino G, Benvenga S. Vitamin D, bone metabolism, and fracture risk in polycystic ovary syndrome. Metabolites. 2021;11(2):116.
19. MotlaghAsghari K, Nejadghaderi SA, Alizadeh M, Sanaie S, Sullman MJM, Kolahi AA, et al. Burden of polycystic ovary syndrome in the Middle East and North Africa region, 1990–2019. Sci Rep. 2022;
12(1):7039.
20. Schröder-Heurich B, Springer CJP, Von Versen-Höynck F. Vitamin D
effects on the immune system from periconception through pregnancy. Nutrients. 2020;12(5):1432.
21. Tavakoli M, Jeddi-Tehrani M, Salek-Moghaddam A, Rajaei S, Mohammadzadeh A, Sheikhhasani S, et al. Effects of 1,25(OH)2 vitamin D3 on cytokine production by endometrial cells of women with recurrent spontaneous abortion. Fertil Steril. 2011;96(3):751-7.
22. Várbíró S, Takács I, Tűű L, Nas K, Sziva RE, Hetthéssy JR, et al. Effects of Vitamin D on fertility, pregnancy and polycystic ovary syndrome – a review. Nutrients. 2022;14(8):1649.
23. Grzesiak M. Vitamin D3 Action within the ovary – an updated review. Physiol Res. 2020;69(3):371-8.
24. Qiu Y, Yuan S, Wang H. Vitamin D status in endometriosis: a systematic review and meta-analysis. Arch Gynecol Obstet. 2020;
302(1):141-52.
25. De Pascali F, Casarini L, Kuhn C, Simoni M, Mahner S, Jeschke U,
et al. Nuclear expression of VDR and AHR is mutually exclusive in glandular cells in endometriosis. Histochem Cell Biol. 2021;156(4):391-9.
26. Tamblyn JA, Susarla R, Jenkinson C, Jeffery LE, Ohizua O, Chun RF, et al. Dysregulation of maternal and placental vitamin D metabolism in preeclampsia. Placenta. 2017;50:70-7.
27. Zhang JY, Wu P, Chen D, Ning F, Lu Q, Qiu X, et al. Vitamin D promotes trophoblast cell induced separation of vascular smooth muscle cells in vascular remodeling via induction of G-CSF. Front Cell Dev Biol. 2020;8:601043.
28. Dimitriadis E, Menkhorst E, Saito S, Kutteh WH, Brosens JJ. Recurrentpregnancyloss. Nat Rev Dis Primers. 2020;6(1):98.
29. Lucas ES, Vrljicak P, Muter J, Diniz-da-Costa MM, Brighton PJ, Kong CS, et al. Recurrent pregnancy loss is associated with a pro-senescent decidual response during the peri-implantation window. Commun Biol. 2020;3(1):37.
30. Tamblyn JA, Pilarski NSP, Markland AD, Marson EJ, Devall A, Hewison M, et al. Vitamin D and miscarriage: a systematic review and meta-analysis. Fertil Steril. 2022;118(1):111-22.
31. Kolcsár M, Berecki B, Gáll Z. Relationship between serum 25-Hydroxyvitamin D levels and hormonal status in infertile women: A retrospective study. Diagnostics. 2023;13(19):3024.
32. Li S, Chen B, Sheng B, Wang J, Zhu X. The associations between serum vitamin D, calcium and uterine fibroids in Chinese women: a case-controlled study. J Int Med Res. 2020;48(5):030006052092349.
33. Harmon QE, Kissell K, Jukic AMZ, Kim K, Sjaarda L, Perkins NJ, et al. Vitamin D and reproductive hormones across the menstrual cycle. Hum Reprod. 2020;35(2):413-23.
34. Cheng M, Song Z, Guo Y, Luo X, Li X, Wu X, et al. 1α,25-Dihydroxyvitamin D3 Improves Follicular Development and Steroid Hormone Biosynthesis by Regulating Vitamin D Receptor in the Layers Model. CIMB. 2023;45(5):4017-34.
35. Parikh G, Varadinova M, Suwandhi P, Araki T, Rosenwaks Z, Poretsky L, et al. Vitamin D regulates steroidogenesis and insulin-like growth factor binding Protein-1 (IGFBP-1) production in human ovarian cells. HormMetab Res. 2010;42(10):754-7.
36. Hong SH, Lee JE, An SM, Shin YY, Hwang DY, Yang SY, et al. Effect of Vitamin D3 on biosynthesis of estrogen in porcine granulosa cells via modulation of steroidogenic enzymes. Toxicol Res. 2017;33(1):49-54.
37. Yao X, Zhang G, Guo Y, EI-Samahy M, Wang S, Wan Y, et al. Vitamin D receptor expression and potential role of vitamin D on cell proliferation and steroidogenesis in goat ovarian granulosa cells. Theriogenology. 2017;102:162-73.
38. Merhi Z, Doswell A, Krebs K, Cipolla M. Vitamin D alters genes involved in follicular development and steroidogenesis in human cumulus granulosa cells. J Clin Endocrinol Metab. 2014;99(6):E1137-45.
39. Souberbielle JC, Cormier C, Cavalier E, Breuil V, Debiais F, Fardellone P, et al. La supplémentation en vitamine D en France chez les patients ostéoporotiques ou à risque d’ostéoporose: données récentes et nouvelles pratiques. Rev Rhum. 2019;86(5):448-52.
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