Abstract
The release of papaverine hydrochloride from tablets using the flow-through cell apparatus in a citric buffer at pH 6.5 was described by the dimensionless equations containing Scherwood, Schmidt and Reynolds numbers. The physicochemical parameters of the dissolution process such as the diffusion coefficient, the mass transfer coefficient, the thickness of the boundary diffusion layer and the concentration of the saturated solution at the boundary diffusion layer in stationary conditions were calculated. The dimensionless equation proposed for interpretation of the release data describes approximately 100 % experimental results.
References
1. Adams E. et al.: Non-linear mixed effects models for the evaluation of dissolution profiles. Int. J. Pharm., 240, 37, 2002.
2. Ahuja N., Katare O.P., et al.: Studies on dissolution enhancement and mathematical modeling of drug release of a poorly water-soluble drug using water-soluble carriers. Eur. J. Pharma Biopharm., 65, 26, 2007.
3. Czarnecki W.: Dissolution of azathioprine from tablets in forced laminar flow of liquid. Pol. J. Pharmacol. Pharm., 33, 2, 251, 1981.
4. Czarnecki W., Kasperek R.: The release of quinidine from alginate macrospheres described by the dimensionless equation of mass transfer in the solid-liquid system. S.T.P.Pharm. Sci., 12, 3, 173, 2002.
5. Czarnecki W.,Trzewik B.: Estimation of diffusion coefficients of medicinal substances by improved Graham’s method. Annales UMCS, Sectio DDD, 1, 13, 109, 1988.
6. Dokoumetzidis A.,Macheras P.: A century of dissolution research: from Noyes and Whitney to the biopharmaceutics classification system. Int. J. Pharm., 321, 1, 2006.
7. European Pharmacopoeia Fifth Edition, 2004. Council of Europe, Starsbourg.
8. Faisant N.,Siepmann J. et al.:Mathematical modeling of drug release from bioerodible microparticles: effect of gamma-irradiation. Eur. J. Pharm. Biopharm., 56, 271, 2003.
9. Fukunaka T., Yaegashi Y. et al:. Dissolution characteristics of cylindrical particles and tablets. Int. J. Pharm., 310, 146, 2006.
10. Grassi M., Zema L. et al.: Modeling of drug release from partially coated matrices made of a high viscosity HPMC. Int. J. Pharm., 276, 107, 2004.
11. Hobler T.: Diffusion of mass transfer and absorbers. The press of sciences and technics, Warsaw 1976.
12. Kallay N.,Senjković R.: Kinetics of drug dissolution from tablets and capsules at high saturation. Pharm. Acta Helv. 62, 12, 337, 1987.
13. Kasperek R.: Determination of diclofenac sodium and papaverine hydrochloride in tablets by HPLC method. Acta Pol. Pharm-Drug Res., 65, 4, 403, 2008.
14. Kasperek R.: The tablets containing of diclofenac sodium with analgetic and spasmolytic effect and their preparation. Polish patent No P-380847, 2006.
15. Kasperek R.: Spectrophotometric determination of diclofenac sodium and papaverine hydrochloride in dosage powders. Annales UMCS, Sectio DDD, 18, 9, 59, 2005.
16. Kiortsis S.,Kachrimanis K. et al.: Drug release from tableted wet granulations comprising cellulosic (HPMC or HPC) and hydrophobic component. Eur. J. Pharm. Biopharm., 59, 73, 2005.
17. Koester L. S.,Ortega G. G.et al.: Mathematical evaluation of in vitro release profiles of hydroxypropylmethylcellulose matrix tablets containing carbamazepine associated to β-cyclodextrin. Eur. J. Pharm. Biopharm., 58, 177, 2004.
18. Kosmidis K., Argyrakis P. et al.: A reappraisal of drug release laws using Monte Carlo simulations: The prevalence of the Weibull function. Pharm. Res., 20, 7, 988, 2003.
19. Le V.N.P.,Leterme P. et al.: Influence of granulation and compaction on the particle size of ibuprofen. Development of a size analysis method. Int. J. Pharm., 321, 72, 2006.
20. Marabi A.,Mayor G. et al.: Assessing dissolution kinetics of powders by a single particle approach. Chem. Eng. J., 139, 118, 2008.
21. Parfitt K. et al. Martindale. The complete drug reference, Thirty-second edition. Pharmaceutical Press, London 1999.
22. Petrus R. et al.:Mass transfer in the solid – liquid phases. The press of the Politechnika Rzeszowska, Rzeszów, 1998.
23. Samani S. M.,Montaseri H. et al.: The effect of polymer blends on release profiles of diclofenac sodium from matrices. Eur. J. Pharm. Biopharm., 55, 351, 2003.
24. Sugano K.: Theoretical comparison of hydrodynamic diffusion layer models used for dissolution simulation in drug discovery and development. Int. J. Pharm., 363, 73, 2008.
25. Tinke A. P.,Vanhoutte K. et al.: A new approach in the prediction of the dissolution behavior of suspended particles by means of their particle size distribution. J. Pharm. Biomed. Anal., 39, 900, 2005.
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 Unported License.
Copyright (c) 2009 Authors