Abstract
A significant complication in vascular surgery is biomaterial infection. The aim of our study was to obtain prolonged antibacterial protection of vascular grafts, employing covalent immobilization of gentamicin and physical adhesion of ciprofloxacin to gelatin-sealed prostheses. The longest (34 days) antibacterial activity (against E. coli) was shown by the hybride biomaterial bounded covalently with gentamicin as well as ionically with ciprofloxacin. In addition, the covalent immobilization of gentamicin enables an antibacterial protection of biomaterial from bacterial adhesion.
References
1. Ashton T. R., Cunningham J. D., Paton D.: Antibiotic loading of vascular grafts. Biomaterials, 13, 235, 1990.
2. Hernandez-Richter H. M., Schardey F., Lohlein M.: The prevention and treatment of vascular graft infection with triclosan (Irgasan®) – bonded Dacron graft: an experimental study in the pig. Eur. J. Vasc. Endovasc. Surg., 20, 413, 2000.
3. KielarM.: Wyniki leczenia późnych zakażeń protez naczyniowych. Polski Przegląd Chirurgiczny, 9, 68, 1999.
4. Lehnhardt F., Torcello G., Claeys L. et al.: Systemic and local antibiotic prophylaxis in the prevention of prosthetic vascular graft infection: En experimentary study. J. Vasc. Endovasc. Surg., 23, 127, 2002.
5. Prager M., Polterauer P., Böhmig H.J. et al.: Collagen vs gelatin-coated dacron vs stretch polytetrafluorethylene in abdominal aortic bifurcation graft surgery: Results of a sevenyear prospective, randomized multicenter trial. Surgery, 130 (3), 408, 2001.
6. Różalska B., Sadowska B., Więckowska M.: Wykrywanie biofilmu bakteryjnego na biomateriałach medycznych. Med. Dośw. Mikrobiol., 50, 115.
7. Strachan C. J., Newsom S. W. Asthon T. R.: The clinical use of the antibiotic-bonded graft. J. Vasc. Surg., 5 (6), 627, 1991.
8. Strachan C. J. L., Edmondson M.: Prosthetic Graft Infection. Int. J. Vasc. Med., 2, 5, 1992.
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