Abstract
Orthopaedic implant infections are a serious problem in present-day medicine. This study is a trial of a new type biomaterial with antimicrobial properties formed by chemical antibiotic immobilization on HAp granules surface. Biomaterial was protected from bacterial adhesion (Staphylococcus aureus ATCC 25923, Staphylococcus aureus MR3, Staphylococcus epidermidis ATCC 12228, Pseudomonas aeruginosa ATCC 27853) and biofilm formation. Biomaterial hybrid showed prolonged antimicrobial activity (20–30 days). Biomaterial was resistant to sterilization process and saved its biological activity. Amikacin-modified HAp granules with regard to its properties could be a profitable biomaterial for future medical applications.
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