Abstract
Deltorphins are peptides isolated from the skin of the Amazonian frogs. Although deltorphins were isolated above 20 years ago they are still the most potent and selective δ-opioid receptor agonists available today. They enhance the release of dopamine in the mesolimbic dopamine system and they are involved in reward effects of drugs. The activity of deltorphins also contains dose-dependent stereotyped pattern of locomotor activity, antinociceptive effect, impact on body temperature and production of antidepressant-like effects in the forced swim test in rats. Therefore, deltorphins are a promising target for the development of novel treatment for several disorders, including depression.
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