Derivative spectrophotometric method for simultaneous determination of sulfadimidine and trimethoprim
DOI:
https://doi.org/10.12923/Abstract
Two derivative spectrophotometric methods: the first derivative bivariate algorithm and zero-crossing method from the derivative spectra were proposed for simultaneous determination of sulfadimidine natrium (SDD-Na) and trimethoprim (TMP). Calibration model for bivariate method was constructed with the use of four linear regression calibration equations – two calibrations for each component at two wavelengths. The results obtained were compared with those from zero-crossing derivative spectrophotometry which employs one linear regression calibration equation for each component. The results for bivariate method are satisfactory with % recovery value 99.1±2.22 for TMP and 99.6±0.71 for SDD-Na. For 0 crossing method % recovery value 104.8±6.9 for TMP and 111.7±7.1 for SDD-Na. Comparison of the obtained results shows that the bivariate procedure gave better results than classical derivative spectrophotometry. The first derivative bivariate calibibration method is simple, low cost and good accuracy spectrophotometric method for the simultaneous determination of TMP in combination with SDD-Na.
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