Erythromycin-induced insensitivity of coagulase-negative staphylococci to telithromycin

Authors

  • Marek Juda Department of Pharmaceutical Microbiology, Department of Bacteriology, Laboratory of Medical Center “Luxmed” of Lublin Author https://orcid.org/0000-0002-0340-5463
  • Bartosz Kędzierski Department of Pharmaceutical Microbiology Author
  • Paweł Rybojad Department of Thoracic Surgery, Medical University of Lublin Author
  • Mariusz Kędra Department of Thoracic Surgery, Medical University of Lublin Author
  • Urszula Nakov Department of Bacteriology, Laboratory of Medical Center “Luxmed” of Lublin Author
  • Anna Malm Department of Pharmaceutical Microbiology Author https://orcid.org/0000-0003-1503-7634

DOI:

https://doi.org/10.12923/

Keywords:

coagulase-negative staphylococci, telithromycin, erythromycin, inducible resistance

Abstract

Telithromycin represents a new group of antibiotics, called ketolides, belonging to  the same family as MLSB (macrolide, lincosamide, streptogramin B) antibiotics. The aim of this study was to determine minimal inhibitory concentration (MIC) of telithromycin for nasopharyngeal, erythromycin-resistant isolates of coagulase-negative staphylococci both in the absence and presence of erythromycin in the medium. The increased MIC values for telithromycin were noted in the presence of erythromycin, suggesting the possibility of erythromycin-mediated induction of resistance to telithromycin in this group of strains. The mechanism and clinical significance of this phenomenon has not been known yet.

References

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Published

2025-04-09

Issue

Vol. 23 No. 2 (2010): Annales UMCS, Pharmacia, Sectio DDD, Volume XXIII

Section

Artykuły

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