The state of oxidant and antioxidant systems in the liver at exposure to low-dose ionizing radiation and influence of Echinacea purpurea tincture

Authors

  • Igor Gerush Bukovinian State Medical University, Department of Medical Chemistry, Department of Pharmacy Author
  • Oleg Gerush Bukovinian State Medical University, Department of Medical Chemistry, Department of Pharmacy Author

DOI:

https://doi.org/10.12923/

Keywords:

Echinacea purpurea, glutathione system, low-dose ionizing radiation, liver, antioxidant-provident status

Abstract

It was established that total single irradiation of rats in the dose of 0.3 Gy caused activation of lipid peroxidation in the liver and considerable changes in the liver antioxidant system. Administration of Echinacea tincture to the irradiated rats contributed to normalization of SOD and catalase activity as well as glutathione system enzymes. Biologic effectiveness of the preparation in the destruction of peroxidation products and their toxic metabolites, stabilization of the organism's antioxidant system state has been caused by biologically active substances in its composition. The use of the tincture before and after the exposure proved to be more effective than that only after irradiation.

References

1. Barrett B.: Medicinal properties of Echinacea: a critical review. Phytomedicine, 10, 66, 2003.

2. Bauer R., Wagner H.: Echinacea Handbuch für Ärzte, Apotheker und andere Naturwissenschaftler. WBA, Stuttgart 1990.

3. Benderitter M., Vincent-Genod L. et al.: The Cell Membrane as a Biosensor of Oxidative Stress Induced by Radiation Exposure: A Multiparameter Investigation. Radiat. Res., 159, 471, 2003.

4. Dalle-Donne I., Rossi R., Colombo R. at al.: Biomarkers of Oxidative Damage in Human Disease. Clin. Chem., 52, 601, 2006.

5. Gerush I., Meshchyshen I., Gerush O.: Glutathione system in the liver of animals with acute toxic hepatitis receiving Echinacea purpurea tincture. Annales UMSC, Sect. DDD, 19, N1, 44, 211, 2006.

6. Joksić G., Petrović S. et al.: Biological effects of Echinacea purpurea on human blood cells. Arh. Hig. Rada Toksikol., 60, 165, 2009.

7. Koroluk M., Ivanova L., Maiorova I.: Metod opredelenia aktivnosti katalazy. Lab. Delo, 1, 16, 1988.

8. Moskaug J., Carlsen H. et al.: Polyphenols and glutathione synthesis regulation. Am. J. Clin. Nutr., 81, 277, 2005.

9. Nashikimi N., Appajik R., Jagi K.: The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochem. and Biophys. Res. Communs., 46, 2, 849, 1972.

10. Otsuka K., Koana T. et al.: Activation of antioxidative enzymes induced by low-dose-rate whole-body gamma irradiation: adaptive response in terms of initial DNA damage. Radiat Res., 166, 474, 2006.

Downloads

Published

2025-04-09

Issue

Vol. 23 No. 2 (2010): Annales UMCS, Pharmacia, Sectio DDD, Volume XXIII

Section

Artykuły

License

Copyright (c) 2010 Authors

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 Unported License.