Assessment of functional reserves of the autonomous control mechanisms on the basis of the heart rate variability analysis under the combined influence of blockers of cardiac activity autonomous control and hypoxia

Authors

  • LYUBOV Panina Danylo Halytskyi Lviv National Medical University, Normal Physiology Department Author
  • Mechyslav Gzhegotskyi Danylo Halytskyi Lviv National Medical University, Normal Physiology Department Author
  • Yuriy Petryshyn Danylo Halytskyi Lviv National Medical University, Normal Physiology Department Author
  • Oleksiy Mysakovets Danylo Halytskyi Lviv National Medical University, Normal Physiology Department Author
  • Ostap Mysakovets Danylo Halytskyi Lviv National Medical University, Normal Physiology Department Author

DOI:

https://doi.org/10.12923/

Keywords:

heart rate variability, atropine, propranolol, hypoxia, white rats

Abstract

We have chosen the introduction of the blocker of M-cholinergic receptors (atropine) and blocker of ß-adrenergic receptor (propranolol) in different doses as a functional loading under hypoxia. During the analysis of spectral power we revealed an increase of the absolute values of HF, MF and LF in comparison with the initial level. As a result of hypoxia on the background introduction of propranolol with the increase of the dose we registered an increase of the statistical indexes. We observed an increase of spectral indexes, which attained unexpectedly high values with the increase of the dose of medicine. It is characteristic that the changes were opposite, comparing to the ones with previous application of atropine.

References

1. Bayevskiy R.M. et al.: Use of principles of prenosological diagnosis for assessing the functional state of the body under stress conditions as exemplified by bus drivers. Fiziol. Cheloveka, 35, 41, 2009.

2. Cerutti C. et al.: Autonomic nervous system and cardiovascular variability in rats: a spectral analysis approach. Am. J. Physiol. Heart Circ. Physiol., 261, H1292, 1991.

3. Fazan R.Jr. et al.: Power spectra of arterial pressure and heart rate in streptozotocin-induced diabetes in rats. Journal of Hypertension., 17, 489, 1999.

4. Goranchuk V.V. et al.: Gipoksiterapiya (Hypoxytherapy). Elbi, St. Petersburg 2003.

5. Murasato Yu. et al.: Effects of systemic hypoxia on R-R interval and blood pressure variabilities in conscious rats. Am. J. Physiol. Heart Circ. Physiol., 275, H797, 1998.

6. Ponikowski P. et al.: Chemoreceptor dependence of very low frequency rhythms in advanced chronic heart failure. Am. J. Physiol. Heart Circ. Physiol., 272, H438, 1997.

7. Souza H.C. et al.: Cardiac sympathetic overactivity and decreased baroreflex sensitivity in L-NAME hypertensive rats. Am. J. Physiol. Heart. Circ. Physiol., 280, H844, 2001.

Downloads

Published

2025-04-09

Issue

Vol. 23 No. 2 (2010): Annales UMCS, Pharmacia, Sectio DDD, Volume XXIII

Section

Artykuły

License

Copyright (c) 2010 Authors

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 Unported License.