Correction of porphyrin exchange disorders in conditions of the combined effect of lead and fluorine

Authors

  • Mechyslav Gzhegotskyi Danylo Halytskyi Lviv National Medical University, Normal Physiology Department Author
  • Yuriy Fedorenko Danylo Halytskyi Lviv National Medical University, Normal Physiology Department Author

DOI:

https://doi.org/10.12923/

Keywords:

lead, fluorine, combined effect, delta aminolaevulinic acid, bioprotectors, correction

Abstract

Protracted influence of Pb(NO3)2 in the dose 36 mg/kg of body weight, NaF in the dose 10 mg/kg of body weight and their combined action impairs heme biosynthesis and is accompanied by increased excretion of δ-ALA with urine. A combined effect of lead and fluorine by the explored effect depends on the term of the factors effect, applied bioprotectors and is due to the independent lead effect, additive and more than additive effect. The leading role in the development of the effect belongs to lead. The simultaneous influence of lead and fluorine can be optimally corrected by the complex of pectin, calcium and triovit, which manifest a synergic action.

References

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Published

2025-04-09

Issue

Vol. 23 No. 2 (2010): Annales UMCS, Pharmacia, Sectio DDD, Volume XXIII

Section

Artykuły

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