Investigation of fibronectin expression by white blood cells in diffuse liver disease of viral etiology

Authors

  • Anna Kulinich Dnipropetrovsk State Medical Academy, Department of Biochemistry, Medical and Pharmaceutical Chemistry, Ukraine Author
  • Anna Maslak Dnipropetrovsk State Medical Academy, Department of Biochemistry, Medical and Pharmaceutical Chemistry, Ukraine Author
  • Iryna Pismenetskaya Dnipropetrovsk State Medical Academy, Department of Biochemistry, Medical and Pharmaceutical Chemistry, Ukraine Author
  • Alexander Minchenko Dnipropetrovsk State Medical Academy, Department of Biochemistry, Medical and Pharmaceutical Chemistry, Ukraine Author
  • Olga Shevchenko Dnipropetrovsk State Medical Academy, Department of Biochemistry, Medical and Pharmaceutical Chemistry, Ukraine Author
  • Alla Shevtsova Dnipropetrovsk State Medical Academy, Department of Biochemistry, Medical and Pharmaceutical Chemistry, Ukraine Author

DOI:

https://doi.org/10.12923/

Keywords:

fibronectin, chronic hepatitis, expression, white blood cells, cirrhosis

Abstract

We investigated plasma and cell fibronectin level in 14 patients with chronic liver diseases. The level of plasma fibronectin was not changed in chronic hepatitis and it was decreased in liver cirrhosis. In chronic hepatitis the number of lymphocytes expressed fibronectin on the surface and inside the cells was increased; in cirrhosis only the lymphocyte amount with intracellular FN was increased. Investigation of the expression of fibronectin by blood cells can be useful for studying molecular mechanisms of immune processes and searching for new medicines.

References

1. Blum S. et al.: Fibronectin on activated T lymphocytes is bound to gangliosides and is present in detergent insoluble microdomains. Immunol. Cell Biol., 83, 167, 2005.

2. Cseh K. et al.: Fibronectin on the surface of human lymphocytes. Immunol. Lett., 6, 301, 1985.

3. Hynes R.O.: Wound healing, inflammation, and fibrosis. In: Fibronectins, Springer Series in Molecular Biology, Springer, New York 1990.

4. Klingenman H.G. et al.: Involvement of fibronectin and its receptor in human lymphocyte proliferation. J. Leukocyte Biol., 50, 464, 1991.

5. Wagner C. et al.: Fibronectin synthesis by activated T-lymphocytes: up-regulation of a surface-associated isoforms with signaling function. Immunology, 99, 532, 2000.

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Published

2010-09-30

Issue

Vol. 23 No. 3 (2010): Annales UMCS, Pharmacia, Sectio DDD, Volume XXIII

Section

Artykuły

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Copyright (c) 2010 Authors

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 Unported License.