Influence of the mixed-metal Cu/Fe complex [Cu(dmen)2][Fe(CN)5(NO)] (dmen=N,N-dimethylethylenediamine) on serum iron and copper levels in experimental anemia of rats

Authors

  • Iryna Byelinska aras Shevchenko National University of Kyiv, Ukraine, Department of Cytophysiology, Laboratory of Biologically Active Substances. Scientific Centre for Radiation Medicine of Academy of Medical Sciences of Ukraine, Kyiv, Department of Hematology, Ukraine Author
  • Taras Rybalchenko aras Shevchenko National University of Kyiv, Ukraine, Department of Cytophysiology, Laboratory of Biologically Active Substances. Scientific Centre for Radiation Medicine of Academy of Medical Sciences of Ukraine, Kyiv, Department of Hematology, Ukraine Author
  • Volodymyr Kokozay Taras Shevchenko National University of Kyiv, Ukraine, Department of Cytophysiology, Laboratory of Biologically Active Substances. Scientific Centre for Radiation Medicine of Academy of Medical Sciences of Ukraine, Kyiv, Department of Hematology, Ukraine Author
  • Olesya Vreshch Taras Shevchenko National University of Kyiv, Ukraine, Department of Cytophysiology, Laboratory of Biologically Active Substances. Scientific Centre for Radiation Medicine of Academy of Medical Sciences of Ukraine, Kyiv, Department of Hematology, Ukraine Author
  • Iryna Dyagil Taras Shevchenko National University of Kyiv, Ukraine, Department of Cytophysiology, Laboratory of Biologically Active Substances. Scientific Centre for Radiation Medicine of Academy of Medical Sciences of Ukraine, Kyiv, Department of Hematology, Ukraine Author
  • Volodymyr Rybalchenko Taras Shevchenko National University of Kyiv, Ukraine, Department of Cytophysiology, Laboratory of Biologically Active Substances. Scientific Centre for Radiation Medicine of Academy of Medical Sciences of Ukraine, Kyiv, Department of Hematology, Ukraine Author

DOI:

https://doi.org/10.12923/

Keywords:

mixed-metal Cu/Fe complex, serum iron, serum copper

Abstract

The aim of the study was to investigate the effect of novel mixed-metal complex [Cu(dmen)2][Fe(CN)5(NO)] (dmen=N,N-dimethylethylenediamine) (code KL447) on dynamics of serum iron and copper in the experimental anemia of rats. At the peak of anemia the serum iron levels were shown to decrease and the copper level – to increase and these retained during 20 days of the recovery period in the anemic group. KL447 increases serum iron and copper levels. These results indicate that the mixed-metal Cu/Fe complex causes the recovery of the serum iron levels and increases the serum copper levels in the experimental anemia of rats and it could be a potential substance for stimulation of erythropoiesis.

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Published

2010-09-30

Issue

Vol. 23 No. 3 (2010): Annales UMCS, Pharmacia, Sectio DDD, Volume XXIII

Section

Artykuły

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