Effect of simultaneous treatment with Ukrain and amitriptyline on selected biochemical serum parameters in rodents
Keywords:
amitriptyline, hepatotoxic effect, rodents, UkrainAbstract
The effects of 10-day treatment of rodents with Ukrain and amitriptyline (AMI) on selected biochemical serum parameters indicating liver function have been examined. In the samples of rodents’ serum AST and ALT activities, total protein and α-fetoprotein (AFP) levels were determined. The results indicated 10-day simultaneous administration of Ukrain and AMI significantly decreased ALT and AST activities in mice (except Ukrain 19 mg/kg with AMI). However, in rats the combined treatment led to ALT activity’s increase when compared with only AMI group as well as an increase or a decrease (Ukrain 14 or 28 mg/kg with AMI, respectively) when compared with only Ukrain group but did not affect AST activity. In mice serum the investigated proteins’ concentrations (total protein and AFP) were significantly enhanced in comparison with proper control groups. However, in rat serum only total protein level was decreased. Therefore, adverse changes in the examined biochemical parameters indicating liver function disorder were observed after combined administration of Ukrain and AMI to rodents. Our results may be helpful in clinical practice to avoid this effect.
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