The influence of iron, selenium and copper deficiencies on the thyroid status, processes of protein and lipid peroxidation in rats in conditions of thyroid hypofunction
DOI:
https://doi.org/10.12923/Keywords:
thyroid status, iodine, iron, selenium, copper deficiencies, processes of protein and lipid peroxidation, system of nitric oxideAbstract
In an experiment on rats changes of the indexes of thyroid status (increase of the level of TSH, decrease of the levels of fT3, fT4) and the balance in the system of thyroid hormones in animals with mono iodine deficiency, a combined deficiency of iodine and iron, selenium or copper were studied. Such disturbances of the functional capability of thyroid were observed on the background of the increase of indexes of lipid and protein peroxidation which was manifested by the increase of the content of dien conjugates, malondialdehyde, oxidative modifications of proteins in the blood serum, tissues of thyroid and cerebrum. In this case the combined deficiency of iodine and iron, selenium or copper was followed by more significant changes of the thyroid status, by the increase of lipoperoxidation, by the decrease of content of nitrite ion in blood serum in comparison to the condition of mono iodine deficiency.
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