Effect of Pb2+ upon antioxidant enzymes activity of rat lymphocytes

Authors

  • Oksana Pershyn Danylo Halytskyi Lviv National Medical University Author
  • Zynoviy Vorobets Danylo Halytskyi Lviv National Medical University Author
  • Oksana Konovart Danylo Halytskyi Lviv National Medical University Author
  • Halyna Antonjak Ivan Franko Lviv National University, Ukraine Author

Keywords:

Pb2+, lymphocytes, lipid peroxidation, antioxidant system

Abstract

The main aim of the present study was to investigate the effect of Pb2+ upon antioxidant enzymes activity of rat lymphocytes after the single dosing lead acetate. It was established that under the influence of lead cations the activities of superoxide dismutase and glutathione reductase decreased, while glutathione peroxidase activity did not change significantly. These effects were accompanied by accumulation of the products of lipid peroxidation (malondialdehyde and lipid hydroperoxides) in rats’ lymphocytes during the initial period of intoxication with heavy metal and normalisation of their concentrations on the 10th day after injection.

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Published

2010-12-30

Issue

Vol. 23 No. 4 (2010): Annales UMCS, Pharmacia, Sectio DDD, Volume XXIII

Section

Artykuły

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