The role of pro-inflammatory interleukin-1β during stress-induced injury without/with microbiota variation

Authors

  • Maryana Savytska Danylo Halytskyi Lviv National Medical University, Taras Shevchenko Kyiv National University, Ukraine Author
  • Oleksandr Virchenko Danylo Halytskyi Lviv National Medical University, Taras Shevchenko Kyiv National University, Ukraine Author
  • Oksana Zayachkivska Danylo Halytskyi Lviv National Medical University, Taras Shevchenko Kyiv National University, Ukraine Author

Keywords:

stress, interleukin-1β, microbiota, multiprobiotic

Abstract

Water immersion restraint stress according to Takagi et al. evoked activation of the immune system in rats, which was manifested in an increase of interleukin-1β level in blood serum within 5 minutes, 24 and 48 hours after completion of the stress action. The largest increase was observed after 48 hours. The injection of multiprobiotic Symbiter® acidophilic concentrated to the rats twice a day after the stress led to a decrease in the level of interleukin-1β in the serum after 24 hours and its normalization after 48 hours after stress action.

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Published

2010-12-30

Issue

Vol. 23 No. 4 (2010): Annales UMCS, Pharmacia, Sectio DDD, Volume XXIII

Section

Artykuły

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Copyright (c) 2010 Authors

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