Influence of combined administration of Ukrain and tricyclic antidepressants on basic biochemical serum parameters of kidney function in rats
DOI:
https://doi.org/10.12923/Keywords:
Ukrain, TCAs, nephrotoxicity, ratsAbstract
Our research was aimed to assess the impact of 10-day simultaneous dosing of Ukrain and tricyclic antidepressants, imipramine (IMI) and amitriptyline (AMI), on basic biochemical parameters of renal function in rats. The concentrations of creatinine, urea and β2-microglobulin were determined in animal serum. Based on the results of the study it was found that 10-day combined administration of Ukrain and IMI decreased creatinine concentration (Ukrain 28 mg/kg) and increased urea level (Ukrain 14mg/kg) in blood serum. The same combination of drugs did not affect the concentration of β2-microglobulin. However, the application of Ukrain and AMI for 10 days resulted in the decrease of creatinine and urea (Ukrain 28 mg/kg) concentrations in the serum of rats. The β2-microglobulin level increased in groups of rodents treated with Ukrain (14 and 28 mg/kg) and AMI compared with Ukrain and decreased in relation to AMI. These adverse fluctuations in the studied biochemical parameters in blood serum of rats may indicate a risk of renal impairment after combined 10-day administration of Ukrain and tricyclic antidepressants. We suppose our conclusions may be useful in clinical practice to avoid the above-mentioned adverse effect.
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