Giant cell tumor of the maxilla - case report and long-term follow-up results
DOI:
https://doi.org/10.12923/Keywords:
giant cell tumor, antiangiogenic therapy, interferon alfa-2aAbstract
Giant cell tumor is a rare disease of the head and neck region. Predominantly giant cell tumor involves the end of long bones. Sometimes it occurs in the head and neck areas, predominantly in mandible and maxilla. The tumor arises from the nonosteogenic stromal cells of the bone marrow.
Giant cell tumors are defined as either aggressive or nonaggressive lesions. An aggressive type tumor is large, rapidly growing, loose and displaced teeth. Nonaggressive type giant cell tumors do not exhibit these signs. Surgery is the most accepted treatment of giant cell tumor. Sometimes surgery can be performed in association with new approaches, in an attempt to avoid recurrence. Surgical treatment can be followed by local injection of steroids or antiangiogenic therapy using interferon alfa-2a.
We report a 17-year-old girl with a large, slowly growing giant cell tumor of the maxilla. The patient was treated with surgical excision.
References
1. Kaban L.B. et al: Angiogenic therapy with interferon alpha for giant cell lesions of the jaws. J Oral Maxillofac Surg. 60, 1103, 2002.
2. Kaban L.B. et al: Angiogenic therapy of a recurrent giant cell tumor of the mandilble with interferon alfa-2a. Pediatrics. 103, 1145, 1999.
3. Oda Y. et al: Giant cell tumor of bone: oncological and functional results of long- term follow- up. Jpn J Clin Oncol. 28, 323, 1998.
4. Oh A. et al Malignant hypercalcemia associated with a parathyroid macrocyst and the early genesis of a giant cell tumor. Am J Otolaryngol. 27, 54, 2006.
5. Weber A.L. et al: Giant- cell tumors of the sphenoid bone in four children: Radiological, clinical, and pathological findings. Skull Base Surg. 4, 163,1997.
Downloads
Published
Issue
Section
License
Copyright (c) 2011 Authors
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 Unported License.
