Abstract
A majority of the Polish population was found to have vitamin D deficiency. The problem was expected to grow in the elderly during the COVID-19 pandemic related lock down. The aim of the study was to compare concentrations of vitamin D in the blood sera of geriatric patients treated in outpatient clinics or hospitalized – and in the methods of treatment used. A retrospective study of the records of patients of the Rheumatology Outpatient Clinic and the Geriatrics Ward in Lublin was conducted.
In 2022, 80 people: 50 hospitalized women (HW) and 30 hospitalized men (HM) were admitted to the Geriatrics Ward in Lublin. Of these, 78 persons had vitamin D levels measured. From the Rheumatology Outpatient Clinic, medical histories of 68 outpatient women (OW) and 27 outpatient men (OM) 60+ were analyzed. In HW and HM, mean vitamin D concentration was 23 ng/ml and in OW and OM 25 ng/ml. The OW and OM with vitamin D concentration <30 received prescription for cholecacliferol 20 000 IU to be administered orally twice a week. The follow-up visit 2 was months later. Out of 47 OW, 17 came for the follow up and their results improved. Out of 21 OM, 100% returned, but their results were less satisfactory. The HW and HM received cholecalciferol 2000 IU. There was no follow-up.
In total, 41% of the outpatient elderly and 55% of the hospitalized had vitamin D concentration <20 ng/ml. Treatment of vitamin D deficiency with 20,000 IU cholecalciferol twice a week for two months is effective.
References
1. Borel P, Caillaud D, Cano NJ. Vitamin D bioavailability: state of the art.Crit Rev Food Sci Nutr.2015;55(9):1193-205.
2. Grigalavicius M, Moan J, Dahlback A, Juzeniene A. Daily, seasonal, and latitudinal variations in solar ultraviolet A and B radiation in relation to vitamin D production and risk for skin cancer.Int J Dermatol.2016;55(1):e23-8.
3. Moldovan HR, Wittlich M, John SM, Brans R, Tiplica GS, Salavastru C, et al. Exposure to solar UV radiation in outdoor construction workers using personal dosimetry.Environ Res.2020; 181:108967.
4. Serrano MA, Cañada J, Moreno JC, Gurrea G. Solar ultraviolet doses and vitamin D in a northern mid-latitude.Sci Total Environ.2017;574:744-50.
5. Cashman KD, Dowling KG, Škrabáková Z, Gonzalez-Gross M, Valtueña J, De Henauw S, et al. Vitamin D deficiency in Europe: pandemic?Am J Clin Nutr.2016;103(4):1033-44.
6. Van Schoor N, Lips P. Global overview of vitamin D status.Endocrinol Metab Clin North Am. 2017;46:845-70.
7. Chaudhry A, Hajat S, Rizkallah N, Abu-Rub A. Risk factors for vitamin A and vitamin D deficiencies in children younger than 5 years in the occupied Palestinian territory: a cross-sectional study.Lancet. 2018;391 (Suppl 2):S3.
8. Hilger J, Friedel A, Herr R. A systematic review of vitamin D status in populations worldwide.Br J Nutr.2013;9:1023.
9. Karczmarewicz E, Czekuć-Kryskiewicz E, Płudowski P. Effect of vitamin D status on pharmacological treatment efficiency-impact on cost- effective management in medicine.Dermatoendocrinology.2013;5:299-304.
10. Luan W, Hammond LA, Vuillermot S. Maternal vitamin d prevents abnormal dopaminergic development and function in a mouse model of prenatal immune activation.Sci Rep. 2018;8(1):9741.
11. Płudowski P, Karczmarewicz E, Chlebna-Sokół D, Czech-Kowalska J, Dębski R, Dobrzańska A, et al. Witamina D: Rekomendacje dawkowania w populacji osób zdrowych oraz w grupach ryzyka deficytów. Wytyczne dla Europy Środkowej 2013 r.Standardy Medyczne/Pediatria. 2013;10:573-8.
12. Close GL. The effects of vitamin D3 supplementation on serum total 25[OH]D concentration and physical performance: a randomised dose-response study.Br J Sprts Med. 2013;47:692-6.
13. Romagnoli E, Mascia ML, Cipriani C, Fassino V, Mazzei F, D’Erasmo E, et al. Short and long-term variations in serum calciotropic hormones after a single very large dose of ergocalciferol (vitamin D2) or cholecalciferol (vitamin D3) in the elderly.J Clin Endocrinol Metab.2008;93(8):3015-20.
14. Cipriani C, Romagnoli E, Scillitani A, Chiodini I, Clerico R, Carnevale V, et al. Effect of a single oral dose of 600,000 IU of cholecalciferol on serum calciotropic hormones in young subjects with vitamin D deficiency: a prospective intervention study.J Clin Endocrinol Metab.2010;95(10):4771-7.
15. Schleicher RL, Sternberg MR, Potischman N, Gahche JJ, Storandt RJ, Maw KL, et al. Supplemental vitamin D increased serum total 25-hydroxyvitamin D in the US adult population during 2007-2014.J Nutr.2021;151(8):2446-54.
16. Sabetta JR, DePetrillo P, Cipriani RJ, Smardin J, Burns LA, Landry ML. Serum 25-hydroxyvitamin d and the incidence of acute viral respiratory tract infections in healthy adults.PLoS One.2010;5(6):e11088.
17. Grant WB. A review of the evidence regarding the solar ultraviolet-B-vitamin D-cancer hypothesis.Standardy Med. 2012;9:610-9.
18. Grant WB. Relation between prediagnostic serum 25-hydroxyvitamin D level and incidence of breast, colorectal, and other cancers.J Photochem Photobiol B: Biol. 2010;101:130-6.
19. Mitri J, Muraru MD, Pittas AG. Vitamin D and type 2 diabetes: a systematic review.Eur J Clin Nutr.2011;65:1005-15.
20. Pittas AG, Nelson J, Mitri J, Hillmann W, Garganta C, Nathan DM, et al. Diabetes Prevention Program Research Group. Plasma 25-hydroxyvitamin D and progression to diabetes in patients at risk for diabetes: an ancillary analysis in the Diabetes PreventionProgram. Diabetes Care.2012;35(3):565-73.
21. Aquino S, Cunha A, Gomes Lima J, Sena-Evangelista K, Gouveia Oliveira A, Cobucci RN, et al. Effects of vitamin D supplementation on cardiometabolic parameters among patients with metabolic syndrome: A systematic review and GRADE evidence synthesis of randomized controlled trials. Heliyon. 2023;9(11):e20845.
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