Vol. 32 No. 4 (2019), Artykuły
Vol. 32 No. 4 (2019)

Challenges in technology of bilayer and multi-layer tablets: a mini-review

Artykuły
Published 2019-12-31
Tomasz Blicharski
Chair and Department of Rehabilitation and Orthopedics, Medical University of Lublin, Lublin, Poland
https://orcid.org/0000-0001-9747-8817
Katarzyna Swiader
Chair and Department of Applied and Social Pharmacy, Medical University of Lublin, Poland
https://orcid.org/0000-0002-9214-927X
Anna Serefko
Chair and Department of Applied and Social Pharmacy, Laboratory of Preclinical Testing, Medical University of Lublin, Poland
https://orcid.org/0000-0002-5732-8950
Sylwia Kulczycka-Mamona
Chair and Department of Applied and Social Pharmacy, Medical University of Lublin, Poland
Michal Kolodziejczyk
Department of Applied Pharmacy, Medical University of Lodz, Poland
Aleksandra Szopa
Chair and Department of Applied and Social Pharmacy, Laboratory of Preclinical Testing, Medical University of Lublin, Poland
https://orcid.org/0000-0002-7756-2904

Keywords

bilayer tablet
multi-layer tablet
challenges in technology
compression

Abstract

Bilayer and multi-layer tablets are enjoying growing popularity among original drug and generic product manufacturers. Multi-layer tablets have many key benefits compared to classic immediate-release tablets. The use of such solid oral dosage forms simplifies dosing regimens in combination therapy, and thus improves patient compliance. However, the technology of multilayer tablets is demanding and requires precise choice of excipients and production parameters with regard to each technological step. The main benefits of multi-layer tablets, certain aspects of their production and the challenges encountered during the compression process are reviewed in this paper.

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