Vol. 32 No. 3 (2019), Artykuły
Vol. 32 No. 3 (2019)

The effects of pomegranate peel extract on recurrent aphthous stomatitis

Artykuły
Published 2019-09-28
Sara Darakhshan
Department of Biology, Faculty of Science, Razi University, Kermanshah, Iran/ Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
https://orcid.org/0000-0003-3611-7916
Mohammad Malmir
Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah Iran
Fereshteh Bagheri
Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
https://orcid.org/0000-0003-1737-9734
Mohsen Safaei
Advanced Dental Sciences Research Laboratory, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah
https://orcid.org/0000-0003-3885-6640
Roohollah Sharifi
Department of Endodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah
https://orcid.org/0000-0001-7917-5409
Masoud Sadeghi
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah
https://orcid.org/0000-0002-3586-3012
Masoud Hatami
Department of Oral and Maxillofacial Medicine, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah
https://orcid.org/0000-0002-5739-9089
Hamid Reza Mozaffari
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah/ Department of Oral and Maxillofacial Medicine, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah
https://orcid.org/0000-0001-9351-1499
Reza Tahvilian
Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah
https://orcid.org/0000-0001-6376-986X
PDF

Keywords

antioxidant
pomegranate peel extract
recurrent aphthous stomatitis

Abstract

As high as 20% of the population is thought to have recurrent aphthous stomatitis (RAS), hence, finding new therapeutic agents may be needed. Pomegranate (Punica granatum), has been extensively used in the folk medicine of many cultures, as it possesses antioxidant, anti-inflammatory and anti-bacterial properties. In this study, it is hypothesized that a topical form of pomegranate peel extract (PPE) may shorten the duration, accelerate the healing and reduce the pain of RAS patients. The presented randomized, double-blind study was conducted on 56 patients. Herein, 28 patients were advised to apply PPE gel, and the other 28 patients were given placebo gel, twice daily for one week. Efficacy evaluations were made at days 0 (before using the gel), 3, 5 and 7. The mean values of ulcer size, pain and healing duration of ulcers were compared in both groups. PPE gel was significantly effective in reducing the pain (p<0.001), ulcer size (p<0.001), and healing duration of ulcers (p<0.001) over a period of one week. PPE in the form of oral gel can be used in the management of aphthous ulcers.

PDF

References

1. Mozaffari HR, Izadi B, Sadeghi M, Rezaei F, Sharifi R, Jalilian F. Prevalence of oral and pharyngeal cancers in Kermanshah province, Iran: A ten-year period. Int J Cancer Res. 2016;12(3-4):169-75.

2. Mozaffari HR, Payandeh M, Ramezani M, Sadeghi M, Mahmoudiahmadabadi M, Sharifi R. Efficacy of palifermin on oral mucositis and acute GVHD after hematopoietic stem cell transplantation (HSCT) in hematology malignancy patients: a meta-analysis of trials. Wspolczesna Onkol. 2017;21(4):299-305.

3. Mozaffari HR, Zavattaro E, Abdolahnejad A, Lopez-Jornet P, Omidpanah N, Sharifi R, Sadeghi M, Shooriabi M, Safaei M. Serum and salivary IgA, IgG, and IgM Levels in oral lichen planus: a systematic review and meta-analysis of case-control studies. Medicina 2018;54:99.

4. Preeti L, Magesh KT, Rajkumar K, Karthik R. Recurrent aphthous stomatitis. J Oral Maxillofac Pathol. 2011;15(3):252-6.

5. Chavan M, Jain H, Diwan N, Khedkar S, Shete A, Durkar S. Recurrent aphthous stomatitis: a review. J Oral Pathol Med. 2012;41: 577-83.

6. Rogers RS. Recurrent aphthous stomatitis: clinical characteristics and associated systemic disorders. Semin Cutan Med Surg. 1997;16: 278-83.

7. Belenguer-Guallar I, Jimenez-Soriano Y, Claramunt-Lozano A. Treatment of recurrent aphthous stomatitis. A literature review. J Clin Exp Dent. 2014;6:168-74.

8. Lansky EP, Newman RA. Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer. J Ethnopharmacol. 2007;109:177-206.

9. Ismail T, Sestili P, Akhtar S. Pomegranate peel and fruit extracts: a review of potential anti-inflammatory and anti-infective effects. J Ethnopharmacol. 2012;143:397-405.

10. Jurenka J. Therapeutic applications of pomegranate (Punica granatum L.): a review. Altern Med Rev. 2008;13:128-44.

11. Afaq F, Saleem M, Krueger CG, Reed JD, Mukhtar H. Anthocyanin-and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-κB pathways and inhibits skin tumorigenesis in CD-1 mice. Int J Cancer. 2005;113:423-33.

12. Negi PS, Jayaprakasha GK. Antioxidant and antibacterial activities of Punica granatum peel extracts. Food Microb Safety. 2003;68:1473-77.

13. Lansky E, Shubert S, Neeman I. Pharmacological and therapeutic properties of pomegranate. InSymposium on production, processing and marketing of pomegranate in the Mediterranean region: advances in research and technology. Semin Mediterraneens (CIHEAM). 2000; 231-5.

14. Pacheco-Palencia LA, Noratto G, Hingorani L, Talcott ST, Mertens-Talcott SU. Protective effects of standardized pomegranate (Punica granatum L.) polyphenolic extract in ultraviolet-irradiated human skin fibroblasts. J Agricultur Food Chem. 2003;56:8434-41.

15. Lee SI, Kim BS, Kim KS, Lee S, Shin KS, Lim JS. Immune-suppressive activity of punicalagin via inhibition of NFAT activation. Biochem Biophysic Res Communications. 2008;371:799-803.

16. Romier B, Van De Walle J, During A, Larondelle Y, Schneider YJ. Modulation of signalling nuclear factor-κB activation pathway by polyphenols in human intestinal Caco-2 cells. Br J Nutr. 2008;100(3): 542-51.

17. Ouachrif A, Khalki H, Chaib S, Mountassir M, Aboufatima R, Farouk L, Benharraf A, Chait A. Comparative study of the anti-inflammatory and antinociceptive effects of two varieties of Punica granatum. Pharm Biol. 2012;50(4):429-38.

18. Cimen MY, Kaya TI, Eskandari G, Tursen U, Ikizoglu G, Atik U. Oxidant/antioxidant status in patients with recurrent aphthous stomatitis. Clin Exp Dermatol. 2003;28:647-50.

19. Karincaoglu Y, Batcioglu K, Erdem T, Esrefoglu M, Genc M. The levels of plasma and salivary antioxidants in the patient with recurrent aphthous stomatitis. J Oral Pathol Med. 2005;34:7-12.

20. Lewkowicz N, Banasik M, Tchorzewski H, Kurnatowska AJ, Lewkowicz P. Predominance of Production of Th1 Type Cytokines in Recurrent Aphthous Ulceration. Dent Med Probl. 2004;42:655-60.

21. Gamez-Meza N, Noriega-Rodríguez JA, Medina-Juarez LA, Ortega-García J, Cazarez-Casanova R, Angulo-Guerrero O. Antioxidant activity in soybean oil of extracts from Thompson grape bagasse. J American Oil Chem Society. 1999;76:1445-7.

22. Field EA, Allan RB. Oral ulceration – aetiopathogenesis, clinical diagnosis and management in the gastrointestinal clinic. Aliment Pharmacol Ther. 2003;18(10):949-62.

23. Saral Y, Coskun BK, Ozturk P, Karatas F, Ayar A. Assessment of salivary and serum antioxidant vitamins and lipid peroxidation in patients with recurrent aphthous ulceration. Tohoku J Exp Med. 2005;206:305-12.

24. Arikan S, Durusoy C, Akalin N, Haberal A, Seckin D. Oxidant/antioxidant status in recurrent aphthous stomatitis. Oral Dis. 2009; 15:512-5.

25. Chidambara Murthy KN, Jayaprakasha GK, Singh RP. Studies on antioxidant activity of pomegranate (Punica granatum) peel extract using in vivo models. J Agric Food Chem. 2002;50:4791-5.

26. Nomura Y, Tamaki Y, Tanaka T, Arakawa H, Tsurumoto A, Kirimura K, et al. Screening of periodontitis with salivary enzyme tests. J Oral Sci. 2006;48:177-83.

27. Sastravaha G, Yotnuengnit P, Booncong P, Sangtherapitikul P. Adjunctive periodontal treatment with Centella asiatica and Punica granatum extracts. A preliminary study. J Int Acad Periodontol. 2003; 4:106-15.

28. Sastravaha G, Gassmann G, Sangtherapitikul P, Grimm WD. Adjunctive periodontal treatment with Centella asiatica and Punica granatum extracts in supportive periodontal therapy. J Int Acad Periodontol. 2005;7(3):70-9.

29. Eguia-del Valle A, Martinez-Conde-Llamosas R, López-Vicente J, Uribarri-Etxebarria A, Aguirre-Urizar JM. Salivary levels of Tumour Necrosis Factor-alpha in patients with recurrent aphthous stomatitis. Med Oral Patol Oral Cir Bucal. 2011;16:33-6.

30. Momen-Beitollahi J, Mansourian A, Momen-Heravi F, Amanlou M, Obradov S, Sahebjamee M. Assessment of salivary and serum antioxidant status in patients with recurrent aphthous stomatitis. Med Oral Patol Oral Cir Bucal. 2010;15(4):557-61.

31. Vasconcelos LC, Sampaio MC, Sampaio FC, Higino JS. Use of Punica granatum as an antifungal agent against candidosis associated with denture stomatitis. Mycoses. 2003;46(5-6):192-6.

32. Batista AL, Lins RD, de Souza Coelho R, do Nascimento Barbosa D, Belém NM, Celestino FJ. Clinical efficacy analysis of the mouth rinsing with pomegranate and chamomile plant extracts in the gingival bleeding reduction. Complement Ther Clin Pract. 2014;20(1): 93-8.

33. Ghalayani P, Zolfaghary B, Farhad AR, Tavangar A, Soleymani B. The efficacy of Punica granatum extract in the management of recurrent aphthous stomatitis. J Res Pharm Pract. 2013;2:88-92.

34. Gavanji S, Larki B, Bakhtari A. The effect of extract of Punica granatum var. pleniflora for treatment of minor recurrent aphthous stomatitis. Integr Med Res. 2014;3(2):83-90.

35. Heber D, Seeram NP, Wyatt H, Henning SM, Zhang Y, Ogden LG, Dreher M, Hill JO. Safety and antioxidant activity of a pomegranate ellagitannin-enriched polyphenol dietary supplement in overweight individuals with increased waist size. J Agric Food Chem. 2007;55: 10050-4.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 Unported License.

Copyright (c) 2019 Autors

Downloads

Download data is not yet available.