Keywords
pressure-assisted capillary electrochromatography
pharmaceutical and biomedical analysis
drugs
Abstract
Pharmaceutical analysis guarantees patient safety all over the world. Thus, continuous development of existing analytical techniques is still very important. Pressurized capillary electrochromatography and pressure-assisted capillary electrochromatography are hybrid separation techniques that combine the selectivity of liquid chromatography and the high separation efficiency of capillary electrophoresis. They use a smaller amount of reagents and samples, hence, reducing the total cost of analysis. Therefore they have found application in a number of pharmaceutical and biomedical analysis. This review article focuses on the use and importance of pressurized and pressure-assisted capillary electrochromatography in pharmaceutical and biomedical analysis, taking into account types of detectors and capillaries used. Despite the fact that pressurized capillary electrochromatography and pressure assisted capillary electrochromatography offer many possibilities and have been available for over a dozen years, they are still underdevelopment and not fully explored.
References
1. Wang XM, Zhang QZ, Yang J, Zhu RH, Zhang J, Cai LJ, Peng WX. Validated HPLC-MS/MS method for simultaneous determination of curcumin and piperine in human plasma. Trop. J. Pharm. Res. 2012;11:621-9.
2. Wollein U, Schramek N. Simultaneous determination of alkyl mesilates and alkyl besilates in finished drug products by direct injection GC/MS. Eur. J. Pharm. Sci. 2012;45:201-4.
3. Aturki Z, Rocco A, Rocchi S, Fanali S. Current applications of miniaturized chromatographic and electrophoretic techniques in drug analysis. J. Pharm. Biomed. Anal. 2014;101:194-220.
4. Grossman PD, Colburn JC. Capillary electrophoresis: theory and practice. Academic Press, Inc, 1992.
5. Bartle KD, Mayers P. Capillary electrochromatography. Royal Society of Chemistry, 2001.
6. Tsuda T. Electrochromatography using high applied voltage. Anal. Chem. 1987;59:521-3.
7. Knox JH, Grant IH. Electrochromatography in packed tubes using 1,5 to 50 µm silica gels and ODS bonded silica gels. Chromatographia. 1991;32 (7-8):317-28.
8. Smith NW, Evans MB. The analysis of pharmaceutical compounds using electrochromatography. Chromatographia. 1994;38:649-57.
9. Boughtflower B, Underwood T. Capillary electrochromatography - Some important considerations in the preparation of packed capillaries and the choice of mobile phase buffers. Chromatographia. 1995;40:329-35.
10. Verhey ER, Tjaden UR. Pseudo-electrochromatography - mass spectrometry: a new alternative. J. Chromatogr. A. 1991;554:339-49.
11. Behnke B, Bayer E. Pressurized gradient electro- high- performance liquid chromatography. J. Chromatogr. A. 1994;680:93-8.
12. Van den Bosch SE, Heemstra S, Kraak JC, Poppe H. Experiences with packed capillary electrochromatography at ambient pressure. J. Chromatogr. A. 1996;755:165-77.
13. GU X, Huang X, Yan C. Recent advances in pressurized capillary electrochromatography. Asian J. Pharmacol. Pharmacokinet. 2006;(6) 4:303-15.
14. Wu Y, Wang Y, Zhao Z, Wu K, Wang Y, Chao Y. Pressurized capillary electrochromatography: instrumentation, columns, and applications. Am.Lab. 2010;42:38-41.
15. Vickers PJ, Smith NW. Normal-phase chiral separations by pressure assisted capillary electrochromatography using the Pirkle type stationary phase Whelk-O 1. J Sep. Sci. 2002;25:1284-90.
16. Wu Y, Wang X, Wu Q, Wu X, Lin X, Xie Z. Separation and determination of structurally related free bile acids by pressurized capillary electrochromatography coupled to laser induced fluorescence detection. Anal. Methods. 2010;2:1927-33.
17. Knox JH. Miniaturisation in pressure and electroendosmotically driven liquid chromatography: Some theoretical considerations. Chromatographia. 1987;24(1):135-43.
18. Yang B, Zhang X, Zhang R. A comparative study on analytical method of total alkaloids from cortex Phellodendri amuren by reversed phse high performance liquid chromatogaphy (RP-HPLC) and pressurized capillary electrochromatography (pCEC). Rev. Bras. Farmacogn. 2011;21(1):16-23.
19. Pesek JJ, Matyska MT, Sukul D. Capillary liquid chromatography and capillary electrochromatography using silica hydride stationary phases. J. Chromatogr. A. 2008;1191:136-40.
20. Wistuba D, Czesla H, Roeder M, Schuring V. Enantiomer separation by pressure-supported electrochromatography using capillaries packed with a permethyl-b-cyclodextrin stationary phase. J. Chromatogr. A. 1998;815:183-8.
21. Vickers PJ, Smith NW. Normal-phase chiral separations by pressure assisted capillary electrochromatography using the Pirkle type stationary phase Whelk-O 1. J. Sep. Sci. 2002;25:1284-90.
22. Lin B, Shi ZG, Zhang HJ, Ng SC, Feng YQ. Perphenylcarbamoylated- cyclodextrin bonden- silica particles as chiral stationary phase for enantioseparation by pressure - assisted capillary electrochromatography. Electrophoresis .2006;27:3057-65.
23. Lin B, Zheng MM, Ng S.C, Feng Y.Q. Development of in- tube solid- phase microextraction coupled to pressure- assisted CEC and its application to the analysis of propranolol enantiomers in human urine. Electrophoresis. 2007;28:2771-80.
24. Qu QS, Mangelings D, Shen F, Hu XY, Yan C, Zhang YK, Heyden YV. Pressurized capillary electrochromatographic assay of trimethoprim impurities using 1 μm particle- based columns. J. Chromatogr. A. 2007;1169:228-34.
25. Chen D, Wang J, Jiang Y, Zhou T, Fan G, Wu Y. Separation and determination of coumarins in Fructus cnidii extracts by pressurized capillary electrochromatography using a packed column with a monolithic outlet frit. J. Pharm. Biomed. Anal. 2009;50:695-702.
26. OuYang X, Luo Y, Wen Z, Wu W, Cao G, Zhu X, Yang L, Wang Y, Dong J. Simultaneuous determination of flumequine and oxolinic acid residues in aquatic products using pressurized capillary electrochromatography. Food Anal. Method. 2014;7:1770-5.
27. Liao S, Wang X, Lin X, Wu X, Xie Z, A moleculary imprinted monolith for the fast chiral separation of antiparasitic drugs by pressurized CEC. J. Sep. Sci. 2010;33:2123-30.
28. Lu M, Zhang L, Li Z, Lu Q, Chen G, Cai Z. A new method for analysis of β2 – agonists in human urine by pressure- assisted capillary electrochromatography couple with electrospray- ionization- mass spectrometry using a silica– based monolithic column. Talanta. 2010;81:1655-61.
29. Liu S, Lin X, Zhang X, Lu H, Xie Z. Off- column amperometric detection for pressurized capillary electrochromatography. Chromatographia. 2010;71:659-65.
30. Cheng J, Zhang L, Lu Q, Lu M, Chen Z, Chen G. pCEC coupling with ESI-MS fot the analysis of β2- agonists and narcotics using poly (1- hexadecene- co- TMPTMA) monolithic column. Electrophoresis. 2010;31:1991-7.
31. Yamada H, Kitagawa S, Ohtani H. Simultaneous separation of water- and fat- soluble vitamins in isocratic pressure- assisted capillary electrochromatography using a methacrylate- based monolithic column. J. Sep. Sci. 2013;36:1980-5.
32. Ye F, Xie Z, Wu X, Lin X, Chen G. et al. Phenylaminopropyl silica monolithic column for pressure assisted capillary electrochromatography. J. Chromatogr. A. 2006;1117:170-5.
33. Liao S, Wang X, Lin X, Xie Z. Preparation and characterization of a molecularly imprinted monolithic column for pressure - assisted CEC separation of nitroimidazole drugs. Electrophoresis. 2010;31:2822-30.
34. Lu M, Zhang L, Feng Q, Xia S, Chi Y, Tong P, Chen G. Pressure assisted capillary electrochromatography with electrospray ionization- mass spectrometry based on silica- based monolithic column for rapid analysis of narcotics. Electrophoresis. 2008;29: 936-43.
35. Huang G, Zeng W, Lian Q, Xie Z. Pressurized CEC of neutral and charged solutes using silica monolithic stationary phases functionalized with 3-(2- aminoethyloamino)propyl ligands. J. Sep. Sci. 2008;31:2244-51.
36. Wang S, Jia L, Chen D. Pressurized CEC with gradient elution for separation of flavonoids from corn. J. Sep. Sci. 2009;32:388-93.
37. Wang J, Wu F, Xia R, Zhao Q, Lin X, Xie Z. Rapid fabriaction of ionic liquid- functionalized monolithic column via in-situ urea - formaldehyde polycondensation for pressurized capillary electrochromatography. J. Chromatogr. A. 2016;1449:100-8.
38. Lu M, Zhang L, Qiu B, Feng Q, Xia S, Chen G. Rapid separation and sensitive detection method for β- blockers by pressure- assisted capillary electrochromatography- electrospray ionization mass spectrometry. J. Chromatogr. A. 2008;1193:156-63.
39. Yan RH, Gao Y, Wang X, Zhang X, Yan C, Wang Y. Selectivity tuning in pressurized capillary electrochromatography with a zwitterionic monolithic column. J. Chromatogr. Sci. 2012;51:468-70.
40. Zhang T, Khadra I, Euerby MR, Skelern GG,Watson DG, Tettey J.N. Simultaneous analysis of basic, acidic and neutral compounds on an endcapped octadecylsilane silica- based monolith by pressure- assisted capillary electrochromatography. Electrophoresis. 2008;29: 944-951.
41. Bryson N, Papillard D. An introductin to OPLC. Operation and applications. LC GC Europe. 2004;22:1-8.
42. Dzido T.H, Płochorz PW, Chomicki A, Hałka-Grysińska A, Polak B. Pressurized planar electrochromatography. J. Chromatogr. A. 2011; 1217 (19):2636-47.
43. Wiszkidenszky A, Maho S, Vegh Z, Ferenczi-Fodor K. Validated, stability- indicating semiquantitative purity test for allyestrenol drug substance and tablet by personal OPLC. J. Planar Chromatogr. 1998;11:463-6.
44. Srivastava S, Misra A, Shukla P.K, Kumar B, Lata S, Rawat A.K.S. A validated over pressured layered chromatography (OPLC) method for separation and quantification of colchicine in Gloriosa superba (L.) tubers form different geographical regions. RSC Adv. 2014;4;60902-6.
45. Hałka A, Płochorz PW, Torbicz A, Dzido TH. Reversed- phase pressurized planar electrochromatography and planar chromatography of acetylsalicylic acid, caffeine and acetaminophen. J. Planar Chromatogr. 2010;23:420-5.
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