Vol. 30 No. 3 (2017), Artykuły
Vol. 30 No. 3 (2017)

TP53 promoter methylation in EBV and HPV associated oropharyngeal carcinoma – a pilot study

Artykuły
Published 2017-12-29
Adrian Jarzynski
Department of Virology, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland
Anastazja Boguszewska
Department of Virology, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland
Ewa Kliszczewska
Department of Virology, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland
Lukasz Rolniak
Department of Virology, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland
Anna Dworzanska
Department of Virology, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland
Malgorzata Polz-Dacewicz
Department of Virology, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland
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Keywords

TP53
methylation
OSCC
EBV
HPV

Abstract

TP 53 promoter methylation was examined in frozen tumor tissue taken from patients with oropharyngeal carcinoma with EBV, HPV and co-infection EBV/HPV. This pilot study was performed on 48 patients. Initial studies indicate a high frequency of methylation in HPV-associated (57.1%) and EBV - associated OSCC (60%) cases, whilst the highest exists in co-infection HPV/EBV (75%). Future studies on a larger group of patients, of the mechanisms of co-infection and their role in oral squamous cell carcinoma, are necessary.

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