Vol. 28 No. 2 (2015), Artykuły
Vol. 28 No. 2 (2015)

An alternative synthesis of Azilsartan: an angiotensin II receptor blocker

Artykuły
Published 2015-07-16
Srinivas Garaga
Chemical Research and Development Department, Aurobindo Pharma Ltd, Survey No: 71&72, Indrakaran Village, Sangareddy Mandal, Medak district, Hyderabad – 502329, Andhra Pradesh, India 2 Department of Engineering Chemistry, A. U. College of Engineering (A), Andhra University, Visakhapatnam – 530003, Andhra Pradesh, India
Nimesh C. Misra
Chemical Research and Development Department, Aurobindo Pharma Ltd, Survey No: 71&72, Indrakaran Village, Sangareddy Mandal, Medak district, Hyderabad – 502329, Andhra Pradesh, India
Ambati V. Raghava Reddy
Chemical Research and Development Department, Aurobindo Pharma Ltd, Survey No: 71&72, Indrakaran Village, Sangareddy Mandal, Medak district, Hyderabad – 502329, Andhra Pradesh, India
Koilpillai Joseph Prabahar
Chemical Research and Development Department, Aurobindo Pharma Ltd, Survey No: 71&72, Indrakaran Village, Sangareddy Mandal, Medak district, Hyderabad – 502329, Andhra Pradesh, India
Chandiran Takshinamoorthy
Chemical Research and Development Department, Aurobindo Pharma Ltd, Survey No: 71&72, Indrakaran Village, Sangareddy Mandal, Medak district, Hyderabad – 502329, Andhra Pradesh, India
Douglas Sanasi
Department of Engineering Chemistry, A. U. College of Engineering (A), Andhra University, Visakhapatnam – 530003, Andhra Pradesh, India
Raghubabu Korupolu
Department of Engineering Chemistry, A. U. College of Engineering (A), Andhra University, Visakhapatnam – 530003, Andhra Pradesh, India
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Keywords

novel intermediates
synthesis and characterization
Azilsartan

Abstract

This paper provides a description of an alternative, novel and commercially viable process which has been developed for the preparation of Azilsartan, a pro-drug of Azilsartan medoxomil, an angiotensin II receptor blocker. The present work also provides a primary account of the synthesis and characterization of the novel intermediates (6, 7 & 10) of Azilsartan, with their spectral data.

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References

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Copyright (c) 2015 Authors

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