Vol. 27 No. 4 (2014), Artykuły
Vol. 27 No. 4 (2014)

Kinetics of the decomposition and the estimation of the stability of 10% aqueous and non-aqueous hydrogen peroxide solutions

Artykuły
Published 2015-03-03
Maria Zun
Chair and Department of Applied Pharmacy, Faculty of Pharmacy, Medical University of Lublin, 1 Chodzki, 20-093 Lublin, Poland
Dorota Dwornicka
Chair and Department of Applied Pharmacy, Faculty of Pharmacy, Medical University of Lublin, 1 Chodzki, 20-093 Lublin, Poland
Katarzyna Wojciechowska
Chair and Department of Applied Pharmacy, Faculty of Pharmacy, Medical University of Lublin, 1 Chodzki, 20-093 Lublin, Poland
Katarzyna Swiader
Chair and Department of Applied Pharmacy, Faculty of Pharmacy, Medical University of Lublin, 1 Chodzki, 20-093 Lublin, Poland
Regina Kasperek
Chair and Department of Applied Pharmacy, Faculty of Pharmacy, Medical University of Lublin, 1 Chodzki, 20-093 Lublin, Poland
Marzena Rzadkowska
Chair and Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Unit., Faculty of Pharmacy with Division of Medical Analytics, Medical University of Lublin, 4a Chodzki, 20-093 Lublin, Poland
Ewa Poleszak
Chair and Department of Applied Pharmacy, Faculty of Pharmacy, Medical University of Lublin, 1 Chodzki, 20-093 Lublin, Poland
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Keywords

hydrogen peroxide
urea
stability
activation energy

Abstract

In this study, the stability of 10% hydrogen peroxide aqueous and non-aqueous solutions with the addition of 6% (w/w) of urea was evaluated. The solutions were stored at 20°C, 30°C and 40°C, and the decomposition of hydrogen peroxide proceeded according to first-order kinetics. With the addition of the urea in the solutions, the decomposition rate constant increased and the activation energy decreased. The temperature of storage also affected the decomposition of substance, however, 10% hydrogen peroxide solutions prepared in PEG-300, and stabilized with the addition of 6% (w/w) of urea had the best constancy.

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References

1. Ahmad S.I.: Control of skin infections by a combined action of ultraviolet A (from sun or UVA lamp) and hydrogen peroxide (HUVA therapy), with special emphasis on leprosy. Med Hypotheses. 4, 484-6, 2001.

2. Alfa M.J., Jackson M.: A new hydrogen peroxide based medical device detergent with germicidal properties: composition with enzymatic cleaners. Am. J. Infect. Control. 29, 168, 2001.

3. Bauer K.H. et al.: (2012). Techonologia postaci leku z elementami biofarmacji. MedPharm Polska.

4. Bittencourt Berge S., et al.: Changes in the stiffness of demineralized dentin following application of tooth whitening agents. Acta Odonto. Scand., 70, 56-60, 2012.

5. Bradecka B., Krystek A.: Preparation of stable sodium percarbonate, an ecologically safe bleach. Przem. Chem. 70, 430, 1991.

6. Dobado J.A., Molina J., Portal D.: Theoretical Study on the Urea-Hydrogen Peroxide 1:1 Complexes. J. Phys. Chem. A. 102(4), 778-784, 1998.

7. Farmakopea Polska wydanie IX (2011). Minister Zdrowia, Urząd Rejestracji Produktów Leczniczych, Wyrobów Medycznych i Produktów Biobójczych, Warszawa.

8. Laat J., Gallard H.: Catalytic Decomposition of Hydrogen Peroxide by Fe(III) in Homogeneous Aqueous Solution: Mechanism and Kinetic Modeling. Environ. Sci. Technol. 33, 2726-2732, 1999.

9. Login R.B. et al.: Stabilization of disinfectant urea-hydrogen peroxide complexes with PVP. US 5,183,901 (Cl. 548-543; C01B15/01), 02 Feb 1993, Appl. 825,359, 24 Jan 1992.

10. López-Lázaro M.: Dual role of hydrogen peroxide in cancer: possible relevance to cancer chemoprevention and therapy. Cancer Lett. 8, 1-8, 2007.

11. Militký J., Čáp J.: Improved parameter estimation in arrhenius type models. Thermochim Acta. 92, 77-80, 1985.

12. Molski M.: Chemia piękna. Polskie Wydawnictwo Naukowe, Warszawa, 2012.

13. Siddiquii S., et al.: A study of hydrogen peroxide decomposition in ammonia-peroxide mixtures (APM). Micro. Eng., 103, 68-73, 2013.

14. Zuń M., et al.: Influence of concentration of the urea on the hydrogen peroxide content in 3% aqueous and non-aqueous solutions stored at different temperatures. Ann UMCS Sect DDD. 2, 47-55, 2011.

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