Thyroid diseases and mental illness together with behavioural disorders versus mental illness together with behavioural disorders and thyroid diseases
DOI:
https://doi.org/10.2478/pjph-2021-0007Keywords:
thyroid diseases, mental disorders, behavioural disorders, Hashimoto diseaseAbstract
Introduction. Numerous authors have undertaken research on the coexistence of mental health disorders and thyroid disease. They have not been able to clearly demonstrate which illness came first.
Aim. The main purpose of this work is to asses the coexistence of thyroid disease with mental health conditions and disorders in behaviour. This work is based on a retrospective study and has shown frequent coexistence of thyroid disease with mental health or behaviour disorders.
Material and methods. The research method was a retrospective study carried out on the basis of medical records of patients of primary care clinics in the city of Lublin. The criterion for qualifying patients for the study was having a diagnosis, according to ICD 10, from at least one of the following groups: thyroid diseases E03-E07, mental health conditions F00-F 99 and behavioral disorders R44-R46.
Results. In total, 243 patients were qualified for the study. In this group 193 people are women and the remaining 50 are men. Among patients with isolated diseases, 28% of them have only diagnosed thyroid disease; every third patient (30%) has diagnosed mental health illness or behavioural disorders. The Fisher test showed a relationship between thyroid diseases and mental health conditions including behavioural disorders (p=0.0000). A group of people with hypothyroidism in the course of Hashimoto’s disease has been identified. The results of the prevalence of the disease were observed dividing by gender and age. Hashimoto’s disease occurs in the group of 15% women and 4% men. Pearson’s Chi2 test showed a relationship between the incidence of Hashimoto’s disease and gender (p=0.037). The quota coefficient showed that this relationship is weak (0.13). The disease is more common in women.
Conclusions. There is a close relationship between the incidence of thyroid disease and mental health illness, including behavioural disorders. Patients with co-morbidity are significantly more likely to present mental illnesses and disorders. The dominance of mental illnesses and disorders is three times higher compared to thyroid diseases.
References
1. The World Health Report: 2001. Mental Health: New Understanding, New Hope. Geneva: World Health Organization; 2001.
2. The Global Burden of Disease: 2004 Update. 2008 Geneva: World Health Organization; 2008.
3. Encyklopedia PWN. [http://encyklopedia.pwn.pl/haslo/Ha-1.shimotochoroba; 3910296.html]
4. Hashimoto H. Zur Kenntniss der lymphomatosen Verande-2. rung der Schilddruse (struma lymphomatosa). Arch Klin Chir. 1912;97:219-48.
5. Antonelli A, Ferrari SM, Corrado A, et al. Autoimmune thyroid disorders. Autoimmun Rev. 2015;14(2):174-80.
6. Duntas L. The Role of iodine and selenium in autoimmune thyroiditis. Horm Metab Res. 2015;47(10):721-6.
7. Migdal AL, Hennessey JV. Psychiatric disorders and thyroid disease. In: Endocrine secrets. Wyd. 6 Philadelphia. Pensylwania: Elsevier Saunders; 2013.
8. Broniarczyk-Czarniak M. Zaburzenia psychiczne współistniejące z chorobą Hashimoto – przegląd piśmiennictwa. Varia Medica. 2018;(2)1:83-90.
9. Lin IC, Chen HH, Yeh SY, et al. Risk of depression, chronic morbidities, and l-thyroxine treatment in Hashimoto thyroiditis in Taiwan: A Nationwide cohort study. Medicine (Baltimore). 2016;95(6):e2842.
10. Lin CL, Yang SN, Shiah IS. Acute mania in a patient with hypothyroidism resulting from Hashimoto’s Thyroiditis. Gen Hosp Psychiatry. 2013;35(6):683.e1-683.e2.
11. Mohamadi A, Davoodi-Makinejad M, Azimi A, Naf-issi S. Personality characteristics in MS patients: The role of avoidant personality. Clin Neurol Neurosurg. 2016;144:23-7.
12. Sierra P, Cámara R, Tobella H, Livianos L. What is the real significance and management of major thyroid disorders in bipolar patients? Rev Psiquiatr Salud Ment. 2014;7:88-95.
13. Bocchetta A, Traccis F, Mosca E, et al. Bipolar disorder and antithyroid antibodies: review and case series. Int J Bipolar Disord. 2016;4(1):5.
14. Lu T, Zhou Z, Wu A, et al. Febrile Hashimoto’s encephalopathy associated with Hashitoxicosis. Acta Neurol Belg. 2015;115(4):811-3.
15. Duntas LH, Maillis A. Hypothyroidism and depression: Salient aspects of pathogenesis and management. Minerva Endocrinol. 2013;38:365-77.
16. Kamble MT, Nandedkar PD, Dharme PV, et al. Thyroid function and mental disorders: An insight into the complex interaction. J Clin Diagn Res. 2013;7:11-4.
17. Duntas L. The Role of iodine and selenium in autoimmune thyroiditis. Horm Metab Res. 2015;47(10):721-6.
18. Bjoro T, Holmen J, Kruger O, et al. Prevalence of thyroid disease, thyroid dysfunction and thyroid peroxidase antibodies in a large, unselected population. The Health Study of Nord-Trondelag (HUNT). Eur J Endocrinol. 2000;143(5):639-47.
19. Fugger G, Dold M, Bartova L, et al. Comorbid thyroid disease in patients with major depressive disorder – results from the European Group for the Study of Resistant Depression (GSRD). Eur Neuropsychopharmacol. 2018;28(6):752-60.
20. Kirim S, Keskek SO, Köksal F, et al. Depression in patients with euthyroid chronic autoimmune thyroiditis. Endocr J. 2012;59(8):705-8.
21. Degner D, Haust M, Meller J, et al. Association between autoimmune thyroiditis and depressive disorder in psychiatric outpatients. Eur Arch Psychiatry Clin Neurosci. 2015;265(1):67-72.
22. Koros C, Economou A, Mastorakos G, et al. A selective memory deficit caused by autoimmune encephalopathy associated with Hashimoto thyroiditis. Cogn Behav Neurol. 2012;25(3):144-8.
23. Hendrick VC, Garrick TR. Endocrine and metabolic disorders. In: Kaplan & Sadock’s comprehensive textbook of psychiatry. Seventh edition on CD-ROM. Pensylwania: Lippincott Williams & Wilkins; 2000.
24. Joffe RT, Pearce EN, Hennessey JV, et al. Subclinical hypothyroidism, mood, and cognition in older adults: A review. Int J Geriatr Psychiatry. 2013;28:111-8.
25. Melmed S, Polonsky K, Larsen P, Kronenberg H. WILLIAMS Textbook of Endocrinology 13th Edition Elsevier; 2015.
26. Delemer B, Aubert JP, Nys P, et al. An observational study of the initial management of hypothyroidism in France: the ORCHIDÉE study. Eur J Endocrinol. 2012;167(6):817-23.
27. Caturegli P, De Remigis A, Rose NR. Hashimoto thyroiditis: clinical and diagnostic criteria. Autoimmun Rev. 2014;13(4-5):391-7.
28. Carta MG, Hardoy MC, Carpiniello B, et al. A case control study on psychiatric disorders in Hashimoto disease and Euthyroid Goitre: Not orly depressive but also anxiety disorders are associated with thyroid autoimmunity. Clin Pract Epidemiol Ment Health. 2005;(1):23.
29. Uysal HB, Ayhan M. Autoimmunity affects health-related quality of life in patients with Hashimoto’s thyroiditis. Kaohsiung J Med Sci. 2016;32(8):427-33.
30. Ayhan MG, Uguz F, Askin R, et al. The prevalence of depression and ankiety disorders in patients with euthyroid Hashimoto’s thyroiditis: a comparative study. Gen Hosp Psychiatry. 2014;36(1):95-8.
31. Joy Mathew C, Jose MT, Elshaikh AO, et al. Is hyperthyroidism a possibile etiology of early onset dementia? Cureus. 2020;12(9):e10603.
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