Application of natural polymers in mucosal diseases of the oral cavity
DOI:
https://doi.org/10.12923/2083-4829/2024-0025Keywords:
biopolymers, polymers, oral mucosa diseasesAbstract
The mucous membrane of the oral cavity is susceptible to various pathological conditions, such as ulcers, inflammations, or tumors. Traditional methods of treating these diseases can come with limitations or trigger undesirable effects. Biopolymers, due to their biocompatibility, biodegradability, low toxicity, and ability to regulate regenerative processes, can offer alternative therapeutic approaches. Among the natural polymers used in the treatment of oral mucosal diseases are hyaluronic acid, chitosan, cellulose, and collagen. PubMed and ResearchGate databases were included for a thorough analysis of applications of biopolymers in the treatment of oral mucosal diseases. Biopolymers have a wide range of applications in dental practice. They can be used in the form of gels, creams, rinses, and patches. Natural polymers are utilized as matrices for drug creation and transport. Thanks to their antibacterial, antifungal, and antiinflammatory properties, they are employed in the treatment of conditions like recurrent aphthous stomatitis, lichen planus, and periodontal diseases. Their potential in alleviating symptoms and enhancing wound healing in ulcerative oral cavity diseases has been demonstrated. Biopolymers have also found use in the treatment of oral cancer by increasing the apoptotic index and sensitizing tumors to radiation and chemotherapy. Biopolymers, due to their advantages and multifaceted effects, can serve as alternative methods for treating oral mucosal diseases compared to traditional approaches. In order to confirm their effectiveness, safety, and practical application, further research and assessment of their long-term effects are necessary.
References
1. Tian KK, Qian ZG, Xia XX. Synthetic biology-guided design and biosynthesis of protein polymers for delivery. Adv Drug Deliv Rev. 2023;194:114728.
2. Paradowska-Stolarz A, Wieckiewicz M, Owczarek A, et al. Natural polymers for the maintenance of oral health: Review of recent advances and perspectives. Int J Mol Sci. 2021;22(19):10337.
3. Pedersen DD, Kim S, Wagner WR. Biodegradable polyurethane scaffolds in regenerative medicine: Clinical translation review. J Biomed Mater Res Part A. 2022;110(8):1460-87.
4. Samui A, Pal K, Karmakar P, et al. In situ synthesised lactobionic acid conjugated NMOFs, a smart material for imaging and targeted drug delivery in hepatocellular carcinoma. Mater Sci Eng C Mater Biol Appl. 2019;98:772-81.
5. Hong F, Qiu P, Wang Y, et al. Chitosan-based hydrogels: From preparation to applications, a review. Int J Biol Macromol. 2022;213:1223-42.
6. Valachová K, Šoltés L. Versatile use of chitosan and hyaluronan in medicine. Molecules. 2021;26(4):1195.
7. Hamedi H, Moradi S, Hudson SM, et al. Chitosan based bioadhesives for biomedical applications: A review. Carbohydr Polym. 2022;279:119100.
8. Desai N, Rana D, Salave S, et al. Chitosan: A potential biopolymer in drug delivery and biomedical applications. Pharmaceutics. 2023;15(4):1313.
9. Gao H, Wu N, Wang N, et al. Chitosan-based therapeutic systems and their potentials in treatment of oral diseases. Int J Biol Macromol. 2022;222(PB):3178-94.
10. Li J, Zhuang S. Antibacterial activity of chitosan and its derivatives and their interaction mechanism with bacteria: current state and perspectives. Eur Polym J. 2020;138:109984.
11. Verlee A, Mincke S, Stevens CV. Recent developments in antibacterial and antifungal chitosan and its derivatives. Carbohydr Polym. 2017;164:268-83.
12. Shih PY, Liao YT, Tseng YK, et al. A potential antifungal effect of chitosan against Candida albicans is mediated via the inhibition of SAGA complex component expression and the subsequent alteration of cell surface integrity. Front Microbiol. 2019;10:602.
13. Saeed A, Haider A, Zahid S, et al. In-vitro antifungal efficacy of tissue conditioner-chitosan composites as potential treatment therapy for denture stomatitis. Int J Biol Macromol. 2019 Mar;125:761-6.
14. Gheorghiță D, Moldovan H, Robu A, et al. Chitosan-based biomaterials for hemostatic applications: A review of recent advances. Int J Mol Sci. 2023;24(13):10540.
15. Shao Y, Zhou H. Clinical evaluation of an oral mucoadhesive film containing chitosan for the treatment of recurrent aphthous stomatitis: a randomized, double-blind study. J Dermatolog Treat. 2020;31(7):739-43.
16. Epstein JB, Villines DC, Baker S. Efficacy of a glycopolymer-based oral rinse upon pain associated with ulcerative and erosive lesions of the oral mucosa: A within-subject pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;126(3):240-5.
17. Adhikari HS, Yadav PN. Anticancer activity of chitosan, chitosan derivatives, and their mechanism of action. Int J Biomater. 2018;2018:27-38.
18. Herdiana Y, Wathoni N, Shamsuddin S, et al. Chitosan-based nanoparticles of targeted drug delivery system in breast cancer treatment. Polymers (Basel). 2021;13(11):1717.
19. de Jesus G, Marques L, Vale N, et al. The effects of chitosan on the healing process of oral mucosa: an observational cohort feasibility split-mouth study. Nanomater (Basel, Switzerland). 2023;13(4).
20. Bayer IS. Hyaluronic acid and controlled release: A review. Molecules. 2020;25(11):2649.
21. Iaconisi GN, Lunetti P, Gallo N, et al. Hyaluronic acid: a powerful biomolecule with wide-ranging applications-a comprehensive review. Int J Mol Sci. 2023;24(12):10296.
22. Salwowska NM, Bebenek KA, Żądło DA, et al. Physiochemical properties and application of hyaluronic acid: a systematic review. J Cosmet Dermatol. 2016;15(4):520-6.
23. Graça MFP, Miguel SP, Cabral CSD, et al. Hyaluronic acid-based wound dressings: A review. Carbohydr Polym. 2020;241:116364.
24. Canciani E, Sirello R, Pellegrini G, et al. Effects of vitamin and amino acid-enriched hyaluronic acid gel on the healing of oral mucosa: in vivo and in vitro study. Medicina (Kaunas). 2021;57(3):285.
25. Casale M, Moffa A, Vella P, et al. Hyaluronic acid: Perspectives in dentistry. A systematic review. Int J Immunopathol Pharmacol. 2016;29(4):572-82.
26. Agha-Hosseini F, Pourpasha M, Amanlou M, et al. Mouthwash containing Vitamin E, triamcinolon, and hyaluronic acid compared to triamcinolone mouthwash alone in patients with radiotherapy-induced oral mucositis: Randomized clinical trial. Front Oncol. 2021;11:614877.
27. Tremolati M, Farronato M, Ferrantino L, et al. Clinical performance evaluation of a hyaluronic acid dental gel for the treatment of traumatic ulcers in patients with fixed orthodontic appliances: a randomized controlled trial. Bioeng (Basel, Switzerland). 2022;9(12):761.
28. Rotaru D, Chisnoiu R, Picos AM, et al. Treatment trends in oral lichen planus and oral lichenoid lesions (Review). Exp Ther Med. 2020;20(6):198.
29. Guo Z-X, Zhang Z, Yan J-F, et al. A biomaterial-based therapy using
30. a sodium hyaluronate/bioglass composite hydrogel for the treatment of oral submucous fibrosis. Acta Biomater. 2023;157:639-54.
31. Taskan MM, Balci Yuce H, Karatas O, et al. Hyaluronic acid with antioxidants improve wound healing in rats. Biotech Histochem. 2021;96(7):536-45.
32. Sun B, Zhang M, Shen J, et al. Applications of cellulose-based materials in sustained drug delivery systems. Curr Med Chem. 2019;26(14):2485-501.
33. Avcioglu NH. Bacterial cellulose: recent progress in production and industrial applications. World J Microbiol Biotechnol. 2022;38(5):86.
34. Alven S, Aderibigbe BA. Chitosan and cellulose-based hydrogels for wound management. Int J Mol Sci. 2020;21(24):9656.
35. Horue M, Silva JM, Berti IR, et al. Bacterial Cellulose-Based Materials as Dressings for Wound Healing. Pharmaceutics. 2023;15(2):1-26.
36. Horue M, Cacicedo ML, Fernandez MA, et al. Antimicrobial activities of bacterial cellulose – Silver montmorillonite nanocomposites for wound healing. Mater Sci Eng C Mater Biol Appl. 2020;116:111152.
37. Picheth GF, Pirich CL, Sierakowski MR, et al. Bacterial cellulose in biomedical applications: A review. Int J Biol Macromol. 2017;104(Pt A):97-106.
38. Abdelhamid HN, Mathew AP. Cellulose-based nanomaterials advance biomedicine: a review. Int J Mol Sci. 2022;23(10):5405.
39. Martin P, Nunan R. Cellular and molecular mechanisms of repair in acute and chronic wound healing. Br J Dermatol. 2015;173(2):370-8.
40. Abka-Khajouei R, Tounsi L, Shahabi N, et al. Structures, properties and applications of alginates. Mar Drugs. 2022;20(6):364.
41. Tyagi P, Agate S, Velev OD, et al. A critical review of the performance and soil biodegradability profiles of biobased natural and chemically synthesized polymers in industrial applications. Environ Sci Technol. 2022;56(4):2071-95.
42. Desai N, Jain SP. Alginate microcapsules for drug delivery. Processes. 2021;9(1):137.
43. Gamboa A, Araujo V, Caro N, et al. Spray freeze-drying as an alternative to the ionic gelation method to produce chitosan and alginate nano-particles targeted to the colon. J. Pharm. Sci. 2015;104(12):4373-85.
44. He Q, Tong T, Yu C, et al. Advances in algin and alginate-hybrid materials for drug delivery and tissue engineering. Mar Drugs. 2022;21(1):14.
45. Ahmad A, Mubarak NM, Jannat FT, et al. A critical review on the synthesis of natural sodium alginate based composite materials: An innovative biological polymer for biomedical delivery applications. Processes. 2021;9(1):1-27.
46. Moshaverinia A, Chen C, Akiyama K, et al. Alginate hydrogel as a promising scaffold for dental-derived stem cells: an in vitro study. J Mater Sci Mater Med. 2012;23(12):3041-51.
47. Elango J, Selvaganapathy PR, Lazzari G, et al. Biomimetic collagen-sodium alginate-titanium oxide (TiO(2)) 3D matrix supports differentiated periodontal ligament fibroblasts growth for periodontal tissue regeneration. Int J Biol Macromol. 2020;163:9-18.
48. Mitrano TI, Grob MS, Carrion F, et al. Culture and characterization of mesenchymal stem cells from human gingival tissue. J Periodontol. 2010;81:917-25.
49. Regy RM, Dignon GL, Zheng W, et al. Sequence dependent phase separation of protein-polynucleotide mixtures elucidated using molecular simulations. Nucleic Acids Res. 2020;48(22):12593-603.
50. Papasotiriou I, Beis G, Iliopoulos AC, et al. Supportive Oligonucleotide Therapy (SOT) as an alternative treatment option in cancer: A preliminary study. In Vivo. 2022;36(2):898-906.
51. Chen R, Dong H, Raval D, et al. Sfrp4 is required to maintain Ctsk-lineage periosteal stem cell niche function. Proc Natl Acad Sci U S A. 2023;120(46):e2312677120.
52. Pan W, Yin W, Yang L, et al. Inhibition of Ctsk alleviates periodontitis and comorbid rheumatoid arthritis via downregulation of the TLR9 signalling pathway. J Clin Periodontol. 2019;46(3):286-96.
53. Picciolo G, Mannino F, Irrera N, et al. PDRN, a natural bioactive compound, blunts inflammation and positively reprograms healing genes in an „in vitro” model of oral mucositis. Biomed Pharmacother. 2021;138:111538.
54. Afrasiabi S, Pourhajibagher M, Raoofian R, et al. Therapeutic applications of nucleic acid aptamers in microbial infections. J Biomed Sci. 2020;27(1):6.
55. Li B, Xin Z, Gao S, et al. SIRT6-regulated macrophage efferocytosis epigenetically controls inflammation resolution of diabetic periodontitis. Theranostics. 2023;13(1):231-49.
56. Ahmed N, Gopalakrishna V, Shetty A, et al. Efficacy of PRF vs PRF + biodegradable collagen plug in post-extraction preservation of socket.
57. J Contemp Dent Pract. 2019;20(11):1323-8.
58. Galitsyna EV, Buianova AA, Kozhukhov VI, et al. Cytocompatibility and osteoinductive properties of collagen-fibronectin hydrogel impregnated with siRNA targeting glycogen synthase kinase 3β: In vitro study. Biomedicines. 2023;11(9):2363.
59. Zhang JC, Song ZC, Xia YR, et al. Extracellular matrix derived from periodontal ligament cells maintains their stemness and enhances redifferentiation via the wnt pathway. J Biomed Mater Res A. 2018;106(1):272-84.
60. Friess W. Collagen – biomaterial for drug delivery. Eur J Pharm Biopharm. 1998;45(2):113-36.
61. Fu H, Yang J, Shen Z, et al. Antibacterial, wet adhesive, and healing-promoting nanosheets for the treatment of oral ulcers. Biomater Sci. 2023;11(9):3214-26.
62. Teodora Tihan G, Ungureanu C, Constantin Barbaresso R, et al. Chloramphenicol collagen sponges for local drug delivery in dentistry. Comptes Rendus Chim. 2015;18(9):986-92.
63. Gao Q, Shang Y, Zhou W, et al. Marine collagen peptides: A novel biomaterial for the healing of oral mucosal ulcers. Dent Mater J. 2022;41(6):850-9.
64. Hu Z, Yang P, Zhou C, et al. Marine collagen peptides from the skin of nile tilapia (Oreochromis niloticus): Characterization and wound healing evaluation. Mar Drugs. 2017;15(4):102.
65. Su K, Wang C. Recent advances in the use of gelatin in biomedical research. Biotechnol Lett. 2015;37(11):2139-45.
66. Ebhodaghe SO. A short review on chitosan and gelatin-based hydrogel composite polymers for wound healing. J Biomater Sci Polym Ed. 2022;33(12):1595-622.
67. Cao H, Wang J, Hao Z, et al. Gelatin-based biomaterials and gelatin as an additive for chronic wound repair. Front Pharmacol. 2024;15:1398939.
68. Kozłowska J, Skopińska-Wiśniewska J, Kaczmarek-Szczepańska B, et al. Gelatin and gelatin/starch-based films modified with sorbitol for wound healing. J Mech Behav Biomed Mater. 2023;148:106205.
69. Park CH, Oh J-H, Jung H-M, et al. Effects of the incorporation of ε-aminocaproic acid/chitosan particles to fibrin on cementoblast differentiation and cementum regeneration. Acta Biomater. 2017;61:134-43.
70. Sheikh Z, Hamdan N, Ikeda Y, et al. Natural graft tissues and synthetic biomaterials for periodontal and alveolar bone reconstructive applications: A review. Biomater Res. 2017;21(1):1-20.
71. Wieckiewicz M, Boening K, Wiland P, et al. Reported concepts for the treatment modalities and pain management of temporomandibular disorders. J Headache Pain. 2015;16(1):1-12.
72. Sahoo N, Sahoo RK, Biswas N, et al. Recent advancement of gelatin nanoparticles in drug and vaccine delivery. Int J Biol Macromol. 2015;81:317-31.
73. Liu M, Lin L, Shao M, et al. Decellularized human amniotic particles reinforced with gelma assist wound healing of the oral mucosa in vivo. Mater Express. 2021;11(7):1092-100.
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