Influence of sterilization on the rheological properties of different types polyacrylic acid gels

Authors

  • Anna Kodym Department of Pharmaceutical Technology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Poland Author
  • Bartłomiej Kubiak Department of Pharmaceutical Technology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Poland Author
  • Karolina Miszk Department of Pharmaceutical Technology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Poland Author
  • Joanna Ronowicz Department of Pharmaceutical Technology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Poland Author
  • Łukasz Pałkowski Department of Pharmaceutical Technology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Poland Author

DOI:

https://doi.org/10.12923/j.2084-980X/25.1/a.17

Keywords:

rheology, ophthalmic gel, Carbopol

Abstract

The aim of the study was to analyze the influence of sterilization conditions on the rheological properties of gels containing polyacrylic acid derivatives (Carbopols: 974P, Ultrez 10 and Ultrez 20). The gels utilized in this study contained 0.5% (w/w) metronidazole, antiprotozoal drug (model drug substance). Their rheological properties were determined: flow curve, yield point, apparent viscosity. Moreover, a statistical analysis of factors (polymer type, polymer concentration, sterilization by autoclaving) was undertaken, and their impact on viscosity, yield point and area under flow curve was ascertained. Among this polymers, gels comprising Carbopol 974P were the most stable to sterilization conditions.

References

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Published

2012-03-30

Issue

Vol. 25 No. 1 (2012): Current Issues of Pharmacy and Medical Sciences

Section

Artykuły

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Copyright (c) 2012 Authors

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