Influence of sterilization on the rheological properties of different types polyacrylic acid gels

Autor

  • Anna Kodym Department of Pharmaceutical Technology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Poland Autor
  • Bartłomiej Kubiak Department of Pharmaceutical Technology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Poland Autor
  • Karolina Miszk Department of Pharmaceutical Technology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Poland Autor
  • Joanna Ronowicz Department of Pharmaceutical Technology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Poland Autor
  • Łukasz Pałkowski Department of Pharmaceutical Technology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Poland Autor

DOI:

https://doi.org/10.12923/j.2084-980X/25.1/a.17

Słowa kluczowe:

rheology, ophthalmic gel, Carbopol

Abstrakt

The aim of the study was to analyze the influence of sterilization conditions on the rheological properties of gels containing polyacrylic acid derivatives (Carbopols: 974P, Ultrez 10 and Ultrez 20). The gels utilized in this study contained 0.5% (w/w) metronidazole, antiprotozoal drug (model drug substance). Their rheological properties were determined: flow curve, yield point, apparent viscosity. Moreover, a statistical analysis of factors (polymer type, polymer concentration, sterilization by autoclaving) was undertaken, and their impact on viscosity, yield point and area under flow curve was ascertained. Among this polymers, gels comprising Carbopol 974P were the most stable to sterilization conditions.

Bibliografia

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Pobrania

Opublikowane

2012-03-30

Numer

Tom 25 Nr 1 (2012): Current Issues of Pharmacy and Medical Sciences

Dział

Artykuły

Licencja

Prawa autorskie (c) 2012 Autorzy

Creative Commons License

Praca jest udostępniana na licencji Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 Unported License.