The role of cyclooxygenase isoforms in the mechanisms of cytoprotection of gastric mucosa under the influence of hexapeptide Arg-a-Asp-Lys-Val-Tyr-Arg

Authors

  • Christina Nasadyuk Danylo Halytsky Lviv National Medical University, Ukraine Author
  • Natalya Panasyuk Danylo Halytsky Lviv National Medical University, Ukraine Author
  • Iryna Fomenko Danylo Halytsky Lviv National Medical University, Ukraine Author
  • Olexandr Sklyarov Danylo Halytsky Lviv National Medical University, Ukraine Author

DOI:

https://doi.org/10.12923/j.2084-980X/25.4/a.23

Keywords:

cyclooxygenase, isoforms, cytoprotection, gastric mucosa

Abstract

In experimental epinephrine-induced gastric lesions in rats it was shown that olygopeptide Arg-α-Asp-Lys-Val-Tyr-Arg exerts cytoprotective effect, evaluated by the decrease of the area and severity of the damage of gastric mucosa as well as decrease of  NOS activity, mainly due to the decrease of iNOS and NO production in gastric mucosa. Selective COX-2 blockade enhanced the cytoprotective action of AALVTA. Nonselective blockade by COX-1 caused significant decrease of the gastroprotective properties of AALVTA, showing involvement of COX-1 isoform in the mechanisms of cytoprotection of GM under the action of this hexapeptide.

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Published

2012-12-28

Issue

Vol. 25 No. 4 (2012): Current Issues of Pharmacy and Medical Sciences

Section

Artykuły

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Copyright (c) 2012 Author

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 Unported License.

How to Cite

Nasadyuk, C., Panasyuk, N., Fomenko, I. ., & Sklyarov, O. (2012). The role of cyclooxygenase isoforms in the mechanisms of cytoprotection of gastric mucosa under the influence of hexapeptide Arg-a-Asp-Lys-Val-Tyr-Arg. Current Issues in Pharmacy and Medical Sciences, 25(4), 446-448. https://doi.org/10.12923/j.2084-980X/25.4/a.23