Abstract
In the experiments on rats with modeled stress-induced damage to gastric mucosa by means of adrenaline (2 mg/kg), we studied the effect of Vit E in the condition of iNOS blockage and injection of L-arginine. Under the blockage of iNOS or injection of L-arginine, precursor of NO-synthases, Vit E was observed to exert a modulatory antioxidant effect. Blockage of iNOS with a simultaneous injection of Vit E results in the enhancement of gastroprotection and a reduction of lipoperoxidation processes with a predominant role of iNOS blockage. Injection of L-arginine and Vit E also induces enhancement of gastroprotective processes realized by a decrease of NO content and intensified activity of SOD.
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