Modification of glycoconjugates signaling pathway duringesophageal barrier injury induced by experimental hypergastrinemia

Roman Pinyajko; Oksana Zayachkivska; Antonina Yaschenko; Mechyslav Gzhegotsky

Vol. 22 No. 3 (2009), Artykuły

Vol. 22 No. 3 (2009)

Modification of glycoconjugates signaling pathway duringesophageal barrier injury induced by experimental hypergastrinemia

Artykuły

Published 2009-09-30

Roman Pinyajko⁺⁻
Oksana Zayachkivska⁺⁻
Antonina Yaschenko⁺⁻
Mechyslav Gzhegotsky⁺⁻

Roman Pinyajko

Danylo Halytskyi Lviv National Medical University, Department of Normal Physiology

Oksana Zayachkivska

Danylo Halytskyi Lviv National Medical University, Department of Normal Physiology

Antonina Yaschenko

Danylo Halytskyi Lviv National Medical University, Department of Normal Physiology

Mechyslav Gzhegotsky

Danylo Halytskyi Lviv National Medical University, Department of Normal Physiology

PDF

Abstract

The article presents lectinohistochemistry results of continuous 28 days’ trophicus influence of gastrin on the esophageal mucosa, induced by daily administration of omeprasol, the potent proton pump inhibitor. Three-fold hypergastrinemia triggering induction of the defensive reaction of modification glycoconjugates signaling pathways is an essential component for esophageal barrier integrity. Evaluated changes of esophageal microcirculation and disorganisation in lamina were tracted as hyperproliferation.

PDF

References

1. Bykov V. L., Iseeva E A.: Defence mechanisms of the surface epithelium of the human esophageal mucosa. Morfologia, 130(6), 12, 2006.

2. Cui G., Waldum H. L.: Physiological and clinical significance of enterochromaffin-like cell activation in the regulation of gastric acid secretion World J. Gastroenterol., 28, 13 (4), 493, 2007.

3. Diaz-Del Consuelo I., Jacques Y., Pizzolato G. P.: Comparison of the lipid composition of porcine buccal and esophageal permiabiiy barriers. Arch. Oral. Biol., 50 (12), 981, 2005.

4. Eroz G., Kaszaki J., Czobel M., Boroz M.: Systemic phosphatidylcholine pretreatment protects canine esophageal mucosa during acute experimental biliary reflux. World J. Gastroenterol. 12 (2), 271, 2006.

5. Hollande F. et al.: Signaling the Junctions in Gut Epithelium. Sci. STKE, 277, 13, 2005.

6. Konturek S. J., Zayachkivska O. S. et al.: Protective influence of melatonin against acute esophageal lesions involves prostaglandins, nitric oxide and sensory nerves. JPP, 58 (2), 371, 2007.

7. Ostrowski J., Mikula M., Karczmarski J., Rubel T.: Molecular defence mechanisms of Barrets metaplasia estimated by an integrative genomics. J. Mol. Med., 84 (10), 872, 2006.

8. Singh P. et al.: Long term omeprazole therapy for reflux esophagitis: follow-up in serum gastrin levels, EC cell hyperplasia and neoplasia. World J. Gastroenterol., 6(6), 789, 2000.

9. Wetscher G. J., Hinder R. A., Kretchmar D.: Duodenogastric reflux causes growth stimulation of foregut mucosa potentiated by gastric acid blockade. Dig. Dis. Sci., 41(11), 2166, 1996.

10. Zayachkivska O. S. et al.: Vyvchennya vazodylyatatornnyh efektiv melatoninu na expresiu lektynovyh receptoriv za umov experymental’noho esophagity in vivo. Bukovyns’kyj Medychnyj Vistnyk, 10, 4, 47, 2006.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 Unported License.

Downloads

Download data is not yet available.