Abstract
In acute experiments on 71 white rats by the method of isolated stomach perfusion by Ghosh and Schild it was established that in rats with an intact nervous system antagonist of central and peripheral AMPA/KA glutamate receptors IEM 1751 did not influence gastric acid secretion (GAS) stimulated by pentagastrin and histamine. In rats after vagotomy IEM 1751 enhanced GAS stimulated by pentagastrin and histamine. We concluded that the excitement of central and peripheral AMPA/KA glutamate receptors had an opposite effect on GAS: activation of central AMPA/KA glutamate receptors leads to an increase of pentagastrin and histamine GAS but activation of peripheral AMPA/KA glutamate receptors leads to a decrease of pentagastrin and histamine GAS. In rats with an intact nervous system IEM 1751 did not influence GAS stimulated by pentagastrin and histamine because we deal with a simultaneous action of IEM 1751 on central and peripheral AMPA/KA glutamate receptors which are activated by endogenous glutamate.
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