Abstract
The aim of this work was to investigate the influence of egg albumin on release profiles of dl-α-tocopherol acetate (VE) capsules. The dissolution medium was constituted by pH 6.8 phosphate buffer containing 0.75, 1.5, 3% (w/v) egg albumin in the presence and absence of 1% (w/v) Tween 20. The dissolution behaviour was fit to Higuchi kinetic model and described by Higuchi equation. The area under dissolution curve (AUDC*) was calculated and compared with the concentration of albumin and dissolution time. The dissolution rate of vitamin E was increased with the concentration of albumin. Viscosity increased with the concentration of albumin for both of media. The influence of nonionic surfactant (Tween 20) on the properties of albumin solution and possible complexation as a result of protein-surfactant interaction was also discussed. The total amount of drug released was the highest for dissolution medium with 3% (w/v) albumin and 1% (w/v) Tween 20, showing beneficial influence of Tween 20 on dissolution rate of vitamin E.
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